Home · Subcategory
Wrinkle / Line
See the procedure group × indication combinations in this category, ranked by evidence score. Grade reflects the volume and quality of research; direction reflects what the papers conclude.
| Grade | Score | Direction | Indication | Procedure group | RCT & meta | Clinical & observational | Case reports | Total papers |
|---|---|---|---|---|---|---|---|---|
| A | 95.6 | Supported | Glabellar lines | Botulinum toxin a | 117 | 37 | 17 | 313 |
| A | 95.1 | Supported | Crow's feet lateral canthal | Botulinum toxin a | 62 | 13 | 13 | 172 |
| A | 95.0 | Supported | Forehead horizontal lines | Botulinum toxin a | 28 | 7 | 9 | 94 |
| A | 94.9 | Supported | Masseter hypertrophy / jaw reduction | Botulinum toxin a | 63 | 42 | 91 | 385 |
| A | 94.4 | Supported | Gummy smile | Botulinum toxin a | 17 | 3 | 19 | 63 |
| B | 74.0 | Supported | Mentalis chin dimpling | Botulinum toxin a | 2 | 4 | 5 | 35 |
| F | 13.8 | Bunny lines (nasalis) | Botulinum toxin a | 2 | 1 | 0 | 20 | |
| F | 13.7 | Perioral vertical lines | Botulinum toxin a | 1 | 1 | 0 | 11 | |
| F | 10.0 | Insufficient | Forehead horizontal lines | EMFACE HIFES RF | 0 | 0 | 0 | 0 |