Botulinum toxin a evidence for Crow's feet lateral canthal

Abstract summary (English) BACKGROUND: Botulinum neurotoxins in aesthetic medicine require reconstitution, which may cause administration errors. OBJECTIVE: To evaluate liquid nivobotulinumtoxinA treatment of lateral canthal lines (LCL) and glabellar lines (GL). MATERIALS AND METHODS: Participants with moderate-to-severe LCL with/without moderate-to-severe GL were enrolled in 2 double-blind randomized clinical trials.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND/OBJECTIVES: Two Phase III randomized controlled trials were conducted in the US (ULTRA I) and Germany (ULTRA II) to investigate the efficacy of incobotulinumtoxinA for simultaneous treatment of upper facial lines (UFLs: glabellar frown lines [GFLs], horizontal forehead lines [HFLs] and lateral canthal lines [LCLs]). PATIENTS/METHODS: Healthy adults with moderate to severe GFLs, HFLs, and symmetrical LCLs...

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase III, Multicenter Study

Abstract summary (English) BACKGROUND: The combined efficacy and durability of botulinum toxin A (BTX) and hyaluronic acid fillers (HA) for canthal wrinkles have not been thoroughly evaluated in randomized clinical trials. AIMS: This study evaluated the efficacy, safety, and durability of the combined treatment protocol of onabotulinumtoxinA and Juvederm Volite VYC-12 (Skinvive) for moderate and severe canthal lines. METHODS: This randomized...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Botulinum neurotoxin type A has played a key role in the treatment of facial rhytides. We aimed to compare the safety and effectiveness of Masport and Dysport as botulinum toxin type A preparations in the treatment of upper face rhytides. METHODS: A double-blind randomized, clinical trial was conducted on adults with at least mild severity (scale 1) for lateral canthal (crow's feet), glabellar, and...

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND: Botulinum neurotoxins in aesthetic medicine require reconstitution before administration, which may be inconvenient and present errors among injectors. OBJECTIVES: The aim of this study was to evaluate the efficacy and safety of ready-to-use nivobotulinumtoxinA liquid formulation for the treatment of glabellar lines (GL) with or without treatment of lateral canthal lines (LCL). METHODS: Two multicenter,...

Journal Article, Clinical Trial, Phase III, Multicenter Study, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Two randomized, double-blind, placebo-controlled, Phase III studies of incobotulinumtoxinA for treating upper facial lines (UFLs; ie, a combination of glabellar frown lines [GFLs], horizontal forehead lines [HFLs], and lateral canthal lines [LCLs]) were conducted in the United States (ULTRA I: NCT04594213) and Germany (ULTRA II: NCT04622254). OBJECTIVES: The aim of this study was to evaluate the safety...

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase III, Multicenter Study

Abstract summary (English) BACKGROUND: Facial rejuvenation is a popular non-surgical treatment, and its treatment safety is of key significance to patients. The purpose of this meta-analysis is to compare the effects of botulinum toxin A and placebo on the occurrence of adverse reactions in facial rejuvenation treatment. OBJECTIVE: According to PRISMA guidelines, a comprehensive search was conducted in Chinese and English databases, and 20...

Journal Article, Meta-Analysis

Abstract summary (English) BACKGROUND: RelabotulinumtoxinA (RelaBoNT-A) is a complex-free, ready-to-use, liquid botulinum toxin A. OBJECTIVE: Efficacy/safety of RelaBoNT-A treatment for lateral canthal lines (LCL). METHODS: Randomized adults received RelaBoNT-A (30 U/side; n = 230) or placebo ( n = 73) during a 6-month, double-blind, Ph3 study (Relabotulinumtoxin Aesthetic Development Study-2 [READY-2]).

Journal Article, Randomized Controlled Trial, Clinical Trial, Phase III, Multicenter Study, Research Support, Non-U.S. Gov't

Abstract summary (English) Background: OnabotulinumtoxinA (OnaA) injection in glabella area appears to be a promising treatment for major depression. However, one major concern of placebo-controlled studies on botulinum toxin injections is to ensure adequate blinding. Patients and Methods: In this context, all subjects of this trial received the active product (OnaA).

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND: The lateral orbital crow's feet area is one for which rejuvenation is most frequently requested by patients. Moreover, lateral canthal wrinkles are a common source of dissatisfaction after rhytidoplasty. Botulinum toxin injection has emerged as a most popular, easy, and effective solution; nevertheless, repeated injections are required periodically for long-term effect.

Journal Article, Systematic Review, Research Support, Non-U.S. Gov't