HA filler crosslinked evidence for Nasolabial fold

Abstract summary (English) BACKGROUND: Hyaluronic acid (HA) dermal fillers are widely used as a nonsurgical treatment for facial aging, including nasolabial folds (NLFs). Because demand for convenient aesthetic procedures increases, new HA products require rigorous comparison with established fillers. OBJECTIVES: The aim of this study was to assess the noninferiority and safety of a new crosslinked HA filler, SkinPlus-HYAL Implant Lidocaine...

Journal Article, Multicenter Study, Randomized Controlled Trial, Equivalence Trial, Comparative Study

Abstract summary (English) BACKGROUND: Hyaluronic acid-based dermal fillers are commonly used to correct prominent nasolabial folds (NLFs), a hallmark of aging. OBJECTIVES: This study aimed to verify the effectiveness and safety of STYLAGE L filler (Laboratoires VIVACY, Archamps, France) vs a well-established comparator, Restylane (Galderma, Uppsala, Sweden), for correcting moderate-to-severe NLFs in Chinese subjects. METHODS: A 12-month,...

Journal Article, Randomized Controlled Trial, Multicenter Study, Equivalence Trial

Abstract summary (English) Skin aging causes cumulative structural, physiological, and progressive skin changes, as well as wrinkles, uneven skin tone, elasticity loss, and skin thinning. We performed a systematic review of nine studies involving 278 participants to assess the efficacy and safety of the stable, hybrid cooperative complexes of high molecular weight hyaluronic acid (HCC-HA) and low molecular weight hyaluronic acid used in...

Journal Article, Systematic Review, Review

Abstract summary (English) BACKGROUND: Injectable Poly-L-lactic acid (PLLA) is effective in restoring mid-face volume and is widely used treating the nasolabial fold (NLF). This study aimed to compare the safety and efficacy of a novel PDLLA based product (PDLLA + non-cross-linked HA; Poly-D, L-lactic acid + hyaluronic acid) with that of a commonly used PLLA for NLF correction. METHODS: In this multi-center, randomized, split-face,...

Journal Article, Multicenter Study, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND: Hyaluronic acid (HA) is established as the gold standard for nasolabial folds (NLFs) correction. However, its use is frequently associated with transient edema and potential migration. These limitations have spurred investigation into collagen-based fillers as viable alternatives characterized by comparable efficacy and a favorable safety profile.

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND: Nasolabial folds (NLFs), the pronounced furrows extending from the base of the nose to the corners of the mouth, tend to deepen and lengthen as a natural consequence of aging. Currently, one of the most prevalent treatments for NLFs involves injectable tissue fillers. Although various types of fillers have been utilized in clinical settings, there exists a paucity of research dedicated to evaluating...

Journal Article, Comparative Study, Meta-Analysis

Abstract summary (English) BACKGROUND: We presented the interim results (6 months) of the trial on the safety and efficacy of poly-L-lactic acid filler (PLLA; Gana V) injection for the correction of nasolabial fold (NLF); however, no long-term follow-up trials through 24 months have been conducted on this topic. OBJECTIVE: We aimed to evaluate the safety and efficacy of Gana V, a new PLLA filler, over 24 months for NLF correction compared...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: Prominent nasolabial folds (NLFs) are a typical manifestation of aging. Hyaluronic acid (HA)-based injectable fillers are commonly used for correction. The NICE Study primarily evaluated non-inferiority of STYLAGE^® L Lidocaine (STYL-L), a cross-linked HA filler with lidocaine, versus the similar product Juvéderm^® ULTRA 3 (JUV-3) in correcting moderate to severe NLFs.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Evolysse Form (EVLF) and Evolysse Smooth (EVLS) (Symatese, Chaponost, France) are new hyaluronic acid fillers created using an innovative cold-crosslinking process. OBJECTIVES: The authors of this study aim to collect safety and effectiveness data on new cold-crosslinked fillers to support the US approval for the correction of moderate-to-severe dynamic facial wrinkles and folds. METHODS: In this...

Journal Article, Randomized Controlled Trial, Multicenter Study, Equivalence Trial

Abstract summary (English) BACKGROUND: The aesthetic use of hyaluronic acid (HA) has led to the development of various commercial HA fillers. Crosslinked HA dermal fillers are commonly used to treat facial wrinkles. This study demonstrated the non-inferiority of the newly developed hyaluronic acid filler by comparing its efficacy and safety to that of the existing hyaluronic acid filler.

Journal Article, Randomized Controlled Trial, Comparative Study, Equivalence Trial