GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Acne / Scar / Texture · Enlarged pores

Nonablative fractional resurfacing evidence for Enlarged pores

B 57.5 / 100 Supported 4 RCT/meta · 3 clinical/observational · 1 case · 13 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2023 Last 5 years 62% Positive results 85% Negative results 1 Korea/Asia 5

Known in Korea as

라셈드MOXI헤일로 레이저

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Comparative analysis of erbium: glass 1550 nm and combined erbium: YAG & Nd: YAG lasers for perioral rejuvenation: a prospective study. Lasers in medical science · 2025 · PMID 40537663

Abstract summary (English) Perioral aging manifests as fine lines, wrinkles, and structural changes, often requiring specialized treatment. Although laser systems are widely used in facial rejuvenation, few studies directly compare their efficacy in perioral rejuvenation. This study evaluates and compares the efficacy and safety of two laser systems-Erbium: glass laser and Nd: YAG combined with Er: YAG laser-for perioral rejuvenation.

Journal Article, Comparative Study, Randomized Controlled Trial

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tier1 Comparison of Intense Pulsed Light With Nonablative Fractional Laser and Picosecond Alexandrite Laser With Diffractive Lens Array for Noninvasive Facial Rejuvenation. Lasers in surgery and medicine · 2025 · PMID 39950332

Abstract summary (English) BACKGROUND: Both nonablative fractional (NAFL) laser combined with intense pulsed light (IPL) and picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) have been documented for their efficacy in facial rejuvenation. OBJECTIVE: To observe the safety and efficacy of PSAL-DLA and IPL-NAFL in the rejuvenation of Chinese individuals. METHODS: Each subject (n = 18) received three treatments on half of...

Journal Article, Comparative Study, Randomized Controlled Trial

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tier1 Comparison of the 1064-nm picosecond laser with fractionated microlens array and 1565-nm non-ablative fractional laser for the treatment of enlarged pores: a randomized, split-face, controlled trial. Lasers in medical science · 2024 · PMID 38396012

Abstract summary (English) PURPOSE: This split-face randomized study compared the efficacy and safety between 1064-nm picosecond laser with fractionated microlens array (MLA) and 1565-nm nonablative fractional laser to treat enlarged pores. METHODS: Participants with enlarged facial pores were enrolled and underwent three consecutive sessions at 2-week intervals with either a 1064-nm picosecond laser with MLA or a 1565-nm nonablative...

Randomized Controlled Trial, Journal Article

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tier2 Efficacy and safety of 1565-nm non-ablative fractional laser versus long-pulsed 1064-nm Nd:YAG laser in treating enlarged facial pores. Lasers in medical science · 2022 · PMID 35971017

Abstract summary (English) Facial pores are visible openings of pilosebaceous follicles, and they are one of the major factors influencing facial skin appearance. This article aims to evaluate and compare the efficacy and safety of 1565-nm non-ablative fractional laser (NAFL) and long-pulsed 1064-nm Nd:YAG laser (LPNY) in treating enlarged facial pores. All subjects were treated with NAFL on their left faces and LPNY on their right.

Clinical Trial, Journal Article

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tier2 Evaluating the safety and efficacy of the 1,440-nm laser in the treatment of photodamage in Asian skin. Lasers in surgery and medicine · 2014 · PMID 24634348

Abstract summary (English) BACKGROUND AND OBJECTIVE: As the demand for diminished procedure-associated downtime continues to increase, nonablative fractional laser resurfacing is becoming a more popular intervention in the progression of photoaging. Patients with pigmented skin and a mild degree of photodamage may be particularly suited for a less intensive laser treatment. In this study, we have evaluated the safety and efficacy of a low...

Clinical Trial, Journal Article

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tier2 Evaluating facial pores and skin texture after low-energy nonablative fractional 1440-nm laser treatments. Journal of the American Academy of Dermatology · 2012 · PMID 23098639

Abstract summary (English) BACKGROUND: The fractionated nonablative 1440-nm laser creates microscopic thermal wounds within the epidermis and the dermis and is used clinically to improve tone, texture, and color of skin. OBJECTIVE: We sought to investigate the use of this device to treat facial pores and to improve skin texture. METHODS: Twenty patients received 6 treatments at the highest tolerable energy level performed 2 weeks apart.

Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

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tier0_review Cosmetic Treatments with Energy-Based Devices in Skin of Color. Facial plastic surgery : FPS · 2023 · PMID 37557909

Abstract summary (English) The use of energy-based devices in cosmetic treatments for patients with higher Fitzpatrick skin types is a topic of concern due to the increased risk of complications such as hyperpigmentation and scarring. Advancements in technology have enabled the development of safe and effective energy-based modalities for improving skin tone, texture, and signs of aging in patients with higher Fitzpatrick skin types. This...

Review, Journal Article

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tier3 The comparison of the efficacy and safety of fractional 1064 nm Nd:YAG picosecond laser and nonablative fractional 1565 nm laser in the treatment of enlarged pores: A prospective split-face study. Lasers in surgery and medicine · 2023 · PMID 36718089

Abstract summary (English) BACKGROUND AND OBJECTIVES: To compare the efficacy and safety of fractional 1064 nm Nd:YAG picosecond laser and nonablative fractional 1565 nm laser in the treatment of enlarged pores. STUDY DESIGN/MATERIALS AND METHODS: Twenty patients received five monthly treatments at months 0, 1, 2, 3, and 4 and were followed up at months 5, 6, and 7. All patients were treated by fractional 1064 nm Nd:YAG picosecond laser...

Case Reports, Research Support, Non-U.S. Gov't, Journal Article

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tier_other Nonablative Fractional Diode Laser Resurfacing (1440 nm and 1927 nm) for Photoaged Skin. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2024 · PMID 39190540

Abstract summary (English) BACKGROUND: Nonablative lasers treat photoaged skin and stimulate new collagen formation while sparing epidermal damage. OBJECTIVE: To evaluate the effectiveness and safety of nonablative fractional diode combination laser skin resurfacing treatment (1440 and 1927 nm) in mild-to-moderate photoaged skin. MATERIALS AND METHODS: The entire face was treated with both 1440-nm and 1927-nm wavelengths per treatment, with a...

Journal Article, Research Support, Non-U.S. Gov't

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tier_other Evaluation of 30% supramolecular salicylic acid followed by 1565-nm non-ablative fractional laser on facial acne and subsequent enlarged pores. Lasers in medical science · 2023 · PMID 36947275

Abstract summary (English) The treatment of acne vulgaris and enlarged pore remains challenging. The 30% supramolecular salicylic acid (SSA) is a newly developed form of SA which affects pathogenic factors of acne. Non-ablative fractional laser (NAFL) promotes remodeling and decreases sebum excretion with minimal side effect.

Journal Article

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