Volume / Contour · Midface volume loss
HA filler crosslinked evidence for Midface volume loss
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2021 Last 5 years 53% Positive results 46% Negative results 4 Korea/Asia 20
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF).
Abstract summary (English) BACKGROUND: Injectable Poly-L-lactic acid (PLLA) is effective in restoring mid-face volume and is widely used treating the nasolabial fold (NLF). This study aimed to compare the safety and efficacy of a novel PDLLA based product (PDLLA + non-cross-linked HA; Poly-D, L-lactic acid + hyaluronic acid) with that of a commonly used PLLA for NLF correction. METHODS: In this multi-center, randomized, split-face,...
Journal Article, Multicenter Study, Randomized Controlled Trial, Comparative Study
View on PubMedtier1 A Multicenter, Randomized, Evaluator-Blind, No-Treatment Controlled Study of YVOIRE Y-Solution 720: A Volumizing Hyaluronic Acid Filler for Midface Volume Deficit.
Abstract summary (English) BACKGROUND: Midface volume deficiency is a common aesthetic concern that can be addressed with dermal fillers. YVOIRE Y-Solution 720 (YYS720) is a hyaluronic acid (HA)-based filler designed for midface augmentation. This study aimed to evaluate the effectiveness and safety of YYS720 in improving midface volume.
Journal Article, Randomized Controlled Trial, Multicenter Study
View on PubMedtier1 Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.
Abstract summary (English) BACKGROUND: The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes the auricles more laterally mimicking the inverse effects of a surgical otoplasty. OBJECTIVE: The purpose of this study is to investigate the aesthetic outcome of the...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Efficacy and Safety of Hyaluronic Acid Fillers for Midface Augmentation: A Systematic Review and Meta-Analysis.
Abstract summary (English) Background and Objectives: Hyaluronic acid (HA) fillers are commonly used for midface augmentation because of their biocompatibility and reversibility. Nonetheless, discussions continue about their effectiveness and safety relative to other options. This systematic review and meta-analysis assess the effectiveness, duration, and side effects of HA fillers in midface volume restoration.
Journal Article, Systematic Review, Meta-Analysis
View on PubMedtier1 Efficacy and Safety of Poly-l-Lactic Acid for Correction of Midfacial Volume Loss and Contour Defects: A Prospective, Multicenter, Randomized, Parallel-Controlled, Evaluator-Blinded, Superiority Trial.
Abstract summary (English) BACKGROUND: Poly-l-lactic acid (PLLA) is widely used in esthetic medicine due to its excellent biocompatibility and biodegradability. This study aimed to evaluate the effectiveness and safety of PLLA facial filler in correcting midfacial volume loss and/or contour defects. METHODS: In this prospective, multicenter, randomized, assessor-blinded, superiority clinical trial, 331 subjects were randomly assigned to...
Journal Article, Multicenter Study, Randomized Controlled Trial, Equivalence Trial
View on PubMedtier1 Efficacy and safety of different hyaluronic acid fillers on cheek volume augmentation: systematic review and network meta-analysis.
Abstract summary (English) BACKGROUND: Various rejuvenation surgeries, including hyaluronic acid (HA) fillers, aim to address mid-face volume loss. However, literature on the comparative efficacy and safety of different HA fillers for the zygomatic area remains limited. METHODS: This systematic review and network meta-analysis (NMA), adhering to NMA PRISMA 2020 and Cochrane guidelines.
Systematic Review, Journal Article, Network Meta-Analysis
View on PubMedtier1 Midface Projection Using Biostimulatory Poly- l -Lactic Acid Injectable Implant: A Subgroup Analysis of the Cheek Wrinkle Trial.
Abstract summary (English) BACKGROUND: Correction of cheek wrinkles using poly- l -lactic acid (PLLA-SCA) was demonstrated in a 12-month study. OBJECTIVE: This analysis assessed change from baseline in lifting effect of PLLA-SCA using a 3D camera to provide additional quantified data. METHODS: Subjects received PLLA-SCA (reconstituted in 8 mL of sterile water + 1 mL of 2% lidocaine) in both cheeks or no treatment (control).
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Restoring long-lasting midface volume in the Asian face with a hyaluronic acid filler: A randomized controlled multicenter study.
Abstract summary (English) BACKGROUND: Hyaluronic acid (HA) filler treatment is a minimally-invasive alternative to surgery to volumize the cheeks. HAVOL (Restylane® Volyme) is a flexible HA filler suited to contouring and volumizing the midface. METHODS: This randomized, evaluator-blinded, no-treatment controlled study evaluated effectiveness and safety of HAVOL for correction of midface volume deficit and...
Journal Article, Randomized Controlled Trial, Multicenter Study
View on PubMedtier1 Validation of a Midfacial Scale and Its Use in a Randomized, Evaluator-Blinded Study of CPM-HA-V.
Abstract summary (English) BACKGROUND: Age-related loss of midfacial contour is frequently corrected using dermal fillers. A validated photonumeric scale is beneficial when evaluating post-treatment aesthetic improvement. OBJECTIVE: To present scale-development activities for the Merz Cheek Fullness Assessment Scale (MCFAS) and report pilot-study results of a hyaluronic-acid filler (Belotero Volume with Lidocaine; CPM-HA-V) to treat...
Randomized Controlled Trial, Journal Article
View on PubMedtier1 Safety and Efficacy of Poly-L-Lactic Acid Filler (Gana V vs. Sculptra) Injection for Correction of the Nasolabial Fold: A Double-Blind, Non-Inferiority, Randomized, Split-Face Controlled Trial.
Abstract summary (English) BACKGROUND: Poly-L-lactic acid (PLLA) fillers have shown excellent results as soft tissue fillers for progressive midface volume enhancement, with long-lasting results and high patient satisfaction. OBJECTIVE: Herein, we investigated the safety and effectiveness of a new PLLA filler (Gana V) in comparison with those of the widely used Sculptra. METHODS: This double-blind, non-inferiority, randomized, split-face...
Randomized Controlled Trial, Journal Article, Equivalence Trial
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