Volume / Contour · Jawline contour definition
HA filler crosslinked evidence for Jawline contour definition
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2023 Last 5 years 74% Positive results 36% Negative results 1 Korea/Asia 7
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 Safety and Effectiveness of Two High-G' Soft Tissue Fillers for Chin Augmentation: A Prospective, Randomized, Comparator-Controlled, Evaluator-Blinded Trial.
Abstract summary (English) BACKGROUND: The chin is a crucial facial feature for overall attractiveness. Lower third imbalance can lead to signs of premature aging and loss of jawline contour. Effective chin augmentation with hyaluronic acid fillers has been demonstrated in the literature.
Journal Article, Randomized Controlled Trial, Comparative Study
View on PubMedtier1 Increasing Facial Attractiveness by Lateralizing the Auricle-Analyzing the Pan-Facial Effects of the Postauricular Injection Technique in Chinese Patient Populations.
Abstract summary (English) BACKGROUND: The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes the auricles more laterally mimicking the inverse effects of a surgical otoplasty. OBJECTIVE: The purpose of this study is to investigate the aesthetic outcome of the...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 VYC-25L Is Safe and Effective for Enhancing the Chin and Jawline by Correcting Chin Retrusion in Chinese Adults.
Abstract summary (English) BACKGROUND: Individuals with chin retrusion may seek chin and lower jawline aesthetic enhancement. OBJECTIVES: To evaluate VYC-25L (Juvéderm Volux XC; Allergan Aesthetics, an AbbVie company), a lidocaine-containing injectable hyaluronic acid dermal filler, for chin retrusion correction. METHODS: In this prospective, Phase 3, multicenter study (NCT04559984), Chinese adults with moderate-to-severe chin retrusion on...
Journal Article, Multicenter Study, Randomized Controlled Trial, Clinical Trial, Phase III
View on PubMedtier1 Microfocused Ultrasound With Visualization (MFU-V) and Hyperdilute Calcium Hydroxylapatite (CaHA-CMC) of the Lower Face and Submentum to Treat Skin Laxity: A Pilot Study Demonstrating Superiority of MFU-V First Followed by Hyperdilute CaHA-CMC.
Abstract summary (English) BACKGROUND: Microfocused ultrasound with visualization (MFU-V) and hyperdilute calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) dermal injections are effective for improving skin laxity in the lower face and submentum by stimulating neocollagenesis and neoelastogenesis. OBJECTIVES: Combining these treatments in an optimal order may inform best practice in aesthetic dermatology. Despite their frequent...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Hyaluronic Acid Filler VYC-25L for Jawline Restoration Yields High Satisfaction, Improved Jawline Measurements, and Sustained Effectiveness Across Skin Types, Age, and Gender for up to 12 Months.
Abstract summary (English) BACKGROUND: A randomized study previously reported demonstration of the safety and efficacy of hyaluronic acid filler VYC-25L for restoring jawline definition. OBJECTIVES: The aim of this study was to evaluate patient-reported outcomes (PROs), objective changes in jawline profile, and safety and effectiveness measures by Fitzpatrick skin phototype (FST), gender, and age following VYC-25L treatment. METHODS: Adults...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Jowl Improvement With Injectable Fillers: Jawline Injections Alone Versus Jawline and Cheek Injections.
Abstract summary (English) BACKGROUND: Jowling is a common aesthetic complaint in aging individuals. OBJECTIVE: Injectable filler placed at the lateral jawline will improve the appearance of jowls, as defined by the Merz Aesthetic Jawline Grading Scale (MAJGS). This improvement will be independent of concomitant injection of filler into the lateral cheek.
Journal Article, Comparative Study, Randomized Controlled Trial
View on PubMedtier1 Safe and Effective Restoration of Jawline Definition With Hyaluronic Acid Injectable Gel VYC-25L: Results From a Randomized Controlled Study.
Abstract summary (English) BACKGROUND: A well-defined jawline improves overall facial aesthetics, motivating patients to seek jawline augmentation. OBJECTIVES: In this study we evaluated the safety and effectiveness of the hyaluronic acid injectable gel VYC-25L for restoring jawline definition. METHODS: In a US multicenter, evaluator-blinded study adults with grade 2 (moderate) or 3 (severe) Allergan Loss of Jawline Definition Scale (ALJDS)...
Journal Article, Randomized Controlled Trial, Multicenter Study
View on PubMedtier1 Long-term duration and safety of Radiesse (+) for the treatment of jawline.
Abstract summary (English) BACKGROUND: Calcium hydroxyapatite (CaHA)-carboxymethylcellulose (CMC)+ has unique properties that make it optimal for lifting, contouring, and defining the jawline. This long-term follow-up of a randomized, multicenter, rater-blinded trial reports efficacy and safety of CaHA-CMC(+) through 48 and up to 60 weeks post-treatment. METHODS: Eligible patients were randomized (2:1) to the treatment or the control/delayed...
Journal Article, Randomized Controlled Trial, Multicenter Study
View on PubMedtier1 Comparative clinical study for the efficacy and safety of two different hyaluronic acid-based fillers with Tri-Hyal versus Vycross technology: A long-term prospective randomized clinical trial.
Abstract summary (English) BACKGROUND: Hyaluronic acid-based fillers have an immediate volumizing effect for the treatment of dermal contour deformities and to smooth dermal depressions formed by the loss of volume. A previous study on 2016-2018 has shown the efficacy and safety of the HA-based filler ART FILLER® Volume on the midface only, but not in a comparative manner. METHODS: In this context, an 18 months prospective randomized...
Randomized Controlled Trial, Journal Article, Equivalence Trial
View on PubMedtier1 A Randomized, Evaluator-Blind, Split-Face Study Evaluating the Safety and Efficacy of Calcium Hydroxylapatite for Jawline Augmentation.
Abstract summary (English) INTRODUCTION: Jawline augmentation with calcium hydroxylapatite has not yet been evaluated in a prospective study with a split-face design. This study aims to perform the first randomized controlled, split-face study on the efficacy and safety of calcium hydroxylapatite for jawline augmentation using the needle and cannula technique. OBJECTIVE: To perform the first randomized controlled, split-face study on the...
Journal Article, Randomized Controlled Trial
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