CaHA filler evidence for Nasolabial fold

Abstract summary (English) BACKGROUND: Nasolabial folds (NLFs), the pronounced furrows extending from the base of the nose to the corners of the mouth, tend to deepen and lengthen as a natural consequence of aging. Currently, one of the most prevalent treatments for NLFs involves injectable tissue fillers. Although various types of fillers have been utilized in clinical settings, there exists a paucity of research dedicated to evaluating...

Journal Article, Comparative Study, Meta-Analysis

Abstract summary (English) BACKGROUND: Injectable biostimulator treatments stimulate endogenous collagen in aging skin, but whether they act through similar pathways is unknown. This study evaluates two biostimulatory agents' effects on genes, expressed proteins, and respective pathways as potential aging biomarkers and treatment outcomes. METHODS: This 13-week, randomized, single-center, comparative study compared volume change and gene...

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) BACKGROUND: Soft tissue fillers are used to improve the appearance of nasolabial folds (NLFs). This study aimed to compare the efficacy and safety of a new calcium hydroxylapatite microsphere hydrogel filler (Aphranel) versus Restylane for correcting NLFs. METHODS: In this multicenter, randomized, double-blind, parallel-grouped, positive-controlled, non-inferiority trial, 210 subjects were randomized to bilateral...

Comparative Study, Equivalence Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: Injectable biostimulators are widely used to improve facial aging signs. This study was performed to compare the genetic pathways affected by 2 different injectable biostimulators. METHODS: Randomized 13-week study (n = 21) comparing gene expression after poly l-lactic acid (PLLA-SCA) and calcium hydroxylapatite (CaHA-R) injections (baseline [BL] and Day 28) as treatment of nasolabial fold wrinkles.

Journal Article, Comparative Study, Randomized Controlled Trial

Abstract summary (English) Calcium hydroxylapatite microspheres in a carrier gel (CaHA; Radiesse®: Merz North America, Inc., Raleigh, NC) is approved by the United States Food and Drug Administration for subdermal implantation for the correction of moderate-to-severe facial wrinkles and folds, such as nasolabial folds (NLFs). Lidocaine is often mixed with injectable dermal fillers to reduce injection pain. A new formulation of CaHA has been...

Journal Article, Multicenter Study, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Despite its increasing usage of facial applications, there is a paucity of objective data regarding calcium hydroxylapatite (CaHA). OBJECTIVES: To systematically evaluate the complications from CaHA injection for facial soft tissue augmentation. METHODS: Published studies on CaHA injection for facial soft tissue enhancement were identified through searches of the PubMed, EMBASE, and Cochrane Controlled...

Journal Article, Meta-Analysis, Systematic Review

Abstract summary (English) BACKGROUND: Dermal fillers have continuingly been under development to increase safety, efficacy, and longevity. Biostimulatory dermal fillers, such as calcium hydroxylapatite fillers, have already been shown to be superior in efficacy compared to nonanimal stabilized hyaluronic acid (NASHA)-based fillers. AIMS: In this randomized split-face study, we compared a novel biostimulatory polycaprolactone (PCL)-based...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Pain and potential adverse events (AE) remain challenges for patients being treated with calcium hydroxylapatite (CaHA; Radiesse), especially CaHA not mixed with an anesthetic. The blunt cannula may provide more comfortable and lower risk delivery of CaHA for nasolabial folds (NLF) correction. OBJECTIVE: This 30-day pilot study was designed to compare the effectiveness and safety of standard needles with...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) The use of calcium hydroxylapatite (Radiesse, BioForm Medical, San Mateo, California) for cosmetic soft tissue augmentation has increased significantly in recent years. Only a handful of authors have reported patient satisfaction data. A meta-analysis of published data was performed using a 5-point scale for patient satisfaction to allow data comparison across studies.

Journal Article, Meta-Analysis

Abstract summary (English) This study aims to investigate the indirect effects of calcium hydroxylapatite (CaHA) injections in the zygomatic and malar regions on the healing of nasolabial folds (NLFs). Given the anatomical complexity and proximity of the nasolabial area, selecting appropriate techniques for CaHA applications is crucial to prevent potential complications. The study is designed to contribute insights into the safety and...

Journal Article, Observational Study