Picosecond laser pigment evidence for PIH

Abstract summary (English) OBJECTIVES: This randomised controlled trial aimed to compare the efficacy of Alexandrite picosecond laser therapy combined with dermal polyrevitalisation (NCTF® 135 HA) with laser therapy alone for reducing the severity of melasma. The outcomes were assessed using 3D imaging and the Dermatology Life Quality Index (DLQI). The secondary objectives were to evaluate the safety and tolerability of the combined...

Comparative Study, Journal Article, Randomized Controlled Trial

Abstract summary (English) Melasma is a chronic hyperpigmentation disorder that disproportionately affects women and individuals with darker skin types, leading to a significant psychosocial burden. This meta-analysis aims to evaluate the safety and efficacy of the 755-nm picosecond alexandrite laser (PSAL) compared with conventional therapies in the management of melasma. PubMed, Ovid Medline, Embase, Cochrane Library, and Google Scholar...

Journal Article, Systematic Review, Meta-Analysis, Review

Abstract summary (English) BACKGROUND: Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus that causes visible pigmentation and significantly impacts quality of life. Current treatments for LPP are limited, with inconsistent outcomes from topical, oral, and laser therapies. The 1064-nm picosecond laser has shown potential in managing pigmented skin disorders; however, evidence regarding its effect on LPP remains scarce.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: The nevus of Ota is an uncommon pigmentary skin condition that causes bluish-gray pigmentation and is traditionally treated with a Q-switched laser. Emerging evidence suggests that the 755-nanometer picosecond alexandrite laser is a safe and effective therapeutic option. We sought to determine the overall effectiveness and safety profile of the 755-nanometer (nm) picosecond alexandrite laser for managing...

Journal Article, Systematic Review, Meta-Analysis

Abstract summary (English) BACKGROUND: Lichen planus pigmentosus (LPP) and erythema dyschromicum perstans (EDP) are dermal hyperpigmentation disorders that disproportionately affect individuals with darker skin and are often resistant to standard therapies. Laser treatment is emerging as a therapeutic option, although optimal parameters and safety remain unclear. OBJECTIVE: To evaluate the efficacy, laser parameters, and safety of laser...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: The picosecond alexandrite laser (PSAL) is a first-line treatment for nevus of Ota. However, low-fluence PSAL (LF-PSAL) that does not produce immediate whitening as treatment endpoint, remains unexplored. OBJECTIVE: To compare the efficacy and safety of LF-PSAL versus conventional high fluence PSAL (HF-PSAL) for treating nevus of Ota.

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) Low-fluence picosecond (LFPS) neodymium-doped yttrium aluminum garnet (Nd: YAG) 1064 nm laser has emerged as a promising treatment for melasma; however, its optimal strategy remains unclear. To evaluate the efficacy and safety of LFPS combined with microlens arrays (MLA) compared with LFPS alone in treating melasma. Thirty patients with melasma received LFPS alone on one side of the face (control [C] side) and LFPS...

Journal Article, Randomized Controlled Trial

Abstract summary (English) OBJECTIVE: This study aims to assess the effectiveness and safety of the 730-nm picosecond laser, the 532-nm picosecond laser, and the Q-switched 694-nm nanosecond laser in treating freckles and solar lentigines. METHODS: The randomized clinical trial included 42 participants who met the specific eligibility criteria for freckles and solar lentigines. On each participant's face, three distinct skin areas affected by...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Scar formation is a common outcome of tissue injury, manifesting as atrophic, hypertrophic, and keloid scars, which can significantly impact quality of life. Laser therapy has emerged as a promising treatment modality for scars, encompassing ablative and non-ablative approaches, yet there are gaps in understanding their comparative efficacy, safety, and patient satisfaction. This study aims to comprehensively review...

Journal Article, Systematic Review, Comparative Study

Abstract summary (English) Various types of lasers and energy-based devices have been used to prevent scar formation following primary surgical wound closure. While picosecond lasers have demonstrated potential in treating hypertrophic scars, limited data exists regarding their role in minimizing surgical scar formation. This study aimed to evaluate the safety and effectiveness of a fractional 1064-nm picosecond laser in reducing scar...

Journal Article, Randomized Controlled Trial