Picosecond laser pigment evidence for Photodamaged skin / texture

Abstract summary (English) BACKGROUND: In recent years, skin photoaging has received increasing attention, and laser therapy has become the most commonly used treatment due to its safety and efficacy; emerging evidence suggests that adjunctive "integrated skincare" may enhance treatment benefits by reducing post-procedural reactions and supporting skin barrier repair. OBJECTIVE: The split-face, double-blind, randomized, placebo-controlled,...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND AND OBJECTIVES: Skin aging, characterized by wrinkles, pigment disorders, and enlarged pores, is driven primarily by photoaging. While a 1064 nm fractional picosecond laser shows efficacy in skin rejuvenation, comparative studies with intense pulsed light (IPL) remain limited. This randomized controlled trial (RCT) aimed to compare the efficacy and safety of the 1064 nm fractional picosecond laser with...

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) To evaluate the efficacy and safety of the combination of the long-pulse 1064 nm neodymium-doped yttrium aluminum garnet (LP1064 nm) laser and picosecond 755 nm alexandrite (P755 nm) laser with a diffractive lens array (DLA) in improving skin photoaging. This prospective, randomized, split-face trial was conducted between April 2024 and February 2025 at two centers. A total of 22 healthy volunteers with facial...

Journal Article, Multicenter Study, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Solar lentigines, resulting from chronic UV exposure, are early signs of photoaging and can significantly affect individuals. AIMS: This systematic review evaluates the efficacy, safety, and tolerability of treatments for solar lentigines in light of a lack of conclusive evidence regarding optimal therapy options. METHODS: A systematic search of PubMed/Medline, EMBASE, Cochrane Library, and...

Systematic Review, Journal Article

Abstract summary (English) BACKGROUND: Both nonablative fractional (NAFL) laser combined with intense pulsed light (IPL) and picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) have been documented for their efficacy in facial rejuvenation. OBJECTIVE: To observe the safety and efficacy of PSAL-DLA and IPL-NAFL in the rejuvenation of Chinese individuals. METHODS: Each subject (n = 18) received three treatments on half of...

Journal Article, Comparative Study, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Pigmented lesions from chronic UV photoaging are extremely common on the face and hands. OBJECTIVE: To evaluate the safety and efficacy of a 532-nm picosecond laser for these types of pigmented lesions. METHODS: This was a single-center, prospective, open-label clinical trial.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Various pigment-specific lasers can be used to treat solar lentigines. However, the most effective treatment options remain to be explored to reduce complications, such as postinflammatory hyperpigmentation, especially in dark-skinned patients. OBJECTIVES: This study aims to compare the efficacy and safety between the KTP 532-nm picosecond laser and the alexandrite 755-nm picosecond laser for the...

Journal Article, Randomized Controlled Trial

Abstract summary (English) To compare the efficacy and safety of 755-nm picosecond alexandrite laser and topical tranexamic acid (TTA) combination therapy with laser monotherapy, for the treatment of melasma and facial rejuvenation. This multicenter, randomized, double-blinded, split-face study enrolled 37 patients who presented with melasma and photoaging. Facial halves were randomized to receive either laser and TTA combination therapy or...

Journal Article, Multicenter Study, Randomized Controlled Trial

Abstract summary (English) BACKGROUND AND OBJECTIVES: To compare the efficacy and safety of 1064-nm and dual-wavelength (532/1064 nm) picosecond Nd:YAG lasers with a holographic optic in the treatment of facial photoaging. STUDY DESIGN/MATERIALS AND METHODS: In this prospective, randomized split-face study, each half of each participant's face was randomly treated with a 1064-nm or 532/1064-nm picosecond laser. All participants underwent five...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND AND OBJECTIVE: The long-term efficacy of a picosecond alexandrite laser (PSAL) with a diffractive lens array (DLA) for the treatment of photoaging is absent. To observe the long-term efficacy of PSAL for the treatment of photoaging. STUDY DESIGN/MATERIALS AND METHODS: Each patient (n = 10) received 10 treatments at 2-week intervals.

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't