Photodynamic therapy evidence for Actinic keratosis

Abstract summary (English) BACKGROUND: Photodynamic therapy and cryotherapy are treatment options for actinic keratosis; however, their efficacy and safety remain debated. AIMS: To perform a high-quality systematic review and meta-analysis exploring the efficacy and safety of photodynamic therapy and cryotherapy in actinic keratosis. METHODS: A systematic search was performed applying the Preferred Reporting Items for Systematic Reviews and...

Journal Article, Systematic Review, Meta-Analysis, Comparative Study, Review

Abstract summary (English) BACKGROUND: Photodynamic therapy (PDT) is recommended as a first-line treatment for multiple actinic keratoses (AK) and field cancerized skin. When using PDT, skin preparation is recommended before application of photosensitizer cream to enhance absorption. Different physical methods exist to remove crusts and scales from the AK lesions.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Actinic keratosis (AK) reflects a field cancerization process in chronically sun-damaged skin, and relapse after diclofenac therapy is a frequent clinical scenario. Field-directed treatments such as 5-fluorouracil (5-FU), tirbanibulin, and photodynamic therapy (PDT) are widely used, yet comparative data in post-diclofenac relapse and the contribution of reflectance confocal microscopy (RCM) to...

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) Daylight photodynamic therapy is currently the preferred treatment for actinic keratosis due to its greater effectiveness and a lower level of pain compared to conventional photodynamic therapy. To enhance the effectiveness of the therapy, especially for hyperkeratotic forms, various pre-treatments are currently available, primarily fractional laser therapy. Until now, there have been few studies investigating skin...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Actinic keratosis is a common precancerous epidermal skin lesion characterized by rough, scaly patches on sun-exposed areas due to chronic UV exposure, and it carries a risk of progressing to squamous cell carcinoma. Both photodynamic therapy and imiquimod cream have been proven to be effective therapeutic option for actinic keratosis. However, there is no comprehensive systematic review that compare the efficacy of...

Journal Article, Systematic Review, Meta-Analysis, Comparative Study, Review

Abstract summary (English) BACKGROUND: Photodynamic therapy (PDT) is widely used for actinic keratosis (AK), but its comparative effectiveness versus conventional therapies remains unclear. OBJECTIVE: To systematically evaluate PDT efficacy compared with cryotherapy, 5-fluorouracil, and imiquimod for AK treatment through meta-analysis. METHODS: We conducted a systematic review and meta-analysis, searching PubMed, Embase, Cochrane, and Web of...

Journal Article, Systematic Review, Meta-Analysis, Comparative Study, Review

Abstract summary (English) In vivo reflectance confocal microscopy (RCM) enables monitoring of non-melanocytic skin cancers (NMSC) treated with non-invasive or minimally invasive therapies. This systematic review analyzed studies on NMSC treated with these therapies and monitored by RCM. A total of 56 articles were included, with 40 focusing on squamous conditions, such as actinic keratosis and squamous cell carcinoma, 15 on basal cell...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Actinic keratoses (AKs) are precancerous lesions that may progress to squamous cell carcinoma (SCC). Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is an established treatment, often preceded by mechanical curettage to enhance photosensitizer penetration. However, curettage is associated with pain and discomfort, necessitating alternative pretreatment strategies, also applicable in daylight...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Combining Vitamin D (VD) with photodynamic therapy (PDT) increases the clearance of actinic keratosis, but whether this might also be true for basal cell carcinoma (BCC) was unknown. PATIENT AND METHODS: In an intra-patient, randomized clinical trial, 35 patients with multiple BCC received 3 sessions of PDT using 20 % ALA (4 hr incubation) and 417 nm light. PDT was preceded by randomized pretreatments...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Traditional red light photodynamic therapy for actinic keratoses (AK) causes significant pain during illumination. OBJECTIVE: To evaluate new short-incubation red light PDT regimens for their pain and efficacy characteristics. METHODS: Patients (n = 30) with facial AK were treated with 10 % ALA gel (no occlusion) and red light (635 nm), after randomization as follows [incubation time, illumination time...

Journal Article, Randomized Controlled Trial