GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Hair Removal · Darker skin (Fitzpatrick IV-VI)

Laser hair removal alexandrite ndyag evidence for Darker skin (Fitzpatrick IV-VI)

B 61.2 / 100 Supported 23 RCT/meta · 41 clinical/observational · 8 case · 167 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2013 Last 5 years 23% Positive results 60% Negative results 11 Korea/Asia 53

Known in Korea as

제모클라리티레이저제모클라리티2레이저 제모겨드랑이 제모아포지 플러스젠틀맥스 프로제모 레이저제모아포지플러스 남성제모

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Assessing the Safety and Efficacy of Picosecond Alexandrite Lasers in the Management of Melasma: A Systematic Review and Meta-Analysis of Randomised Control Trials. The Australasian journal of dermatology · 2026 · PMID 41589005

Abstract summary (English) Melasma is a chronic hyperpigmentation disorder that disproportionately affects women and individuals with darker skin types, leading to a significant psychosocial burden. This meta-analysis aims to evaluate the safety and efficacy of the 755-nm picosecond alexandrite laser (PSAL) compared with conventional therapies in the management of melasma. PubMed, Ovid Medline, Embase, Cochrane Library, and Google Scholar...

Journal Article, Systematic Review, Meta-Analysis, Review

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tier1 Comparative efficacy and safety of the novel Picosecond Alexandrite Laser and the traditional combined Q-switched and long-pulse Nd: YAG lasers in melasma treatment: a randomized evaluator-blinded trial. Lasers in medical science · 2025 · PMID 39843829

Abstract summary (English) Melasma significantly impacts life quality, and while various laser therapies show promise, rigorous comparative studies, especially between the novel Picosecond Alexandrite Laser (PSAL) and the traditional combined modality of Q-switched and Long-pulse Nd: YAG Lasers (QLNYL), are notably lacking. This study aims to fill this gap by evaluating the efficacy and safety of these modalities, providing insights into...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 Laser and Light-Based Therapies for Hirsutism Management in Women With Polycystic Ovarian Syndrome: A Systematic Review. JAMA dermatology · 2024 · PMID 38630483

Abstract summary (English) IMPORTANCE: Hirsutism represents a significant concern for women with polycystic ovary syndrome (PCOS), with deleterious psychological effects warranting acknowledgment and a clear imperative to provide effective management. To our knowledge, this is the first review to exclusively examine the effectiveness of laser and light-based therapies in addressing hirsutism in women with PCOS. OBJECTIVE: To synthesize the...

Journal Article, Systematic Review

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tier1 Comparative effectiveness of ice packs versus topical lidocaine-prilocaine mixture for pain control in laser hair removal of the axilla: A rater-blinded randomized controlled trial. Journal of the American Academy of Dermatology · 2022 · PMID 36410628

Abstract summary (English) BACKGROUND: Laser hair removal is associated with moderate acute pain. OBJECTIVE: To compare effectiveness of ice pack to topical lidocaine-prilocaine for pain reduction during axillary laser hair removal. METHODS: Participants were randomly assigned to receive topical anesthetic to one axilla and ice packs to the other before each of 3, monthly 810 nm diode laser sessions.

Randomized Controlled Trial, Journal Article

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tier1 Hair Removal With Blended 755/1064 nm Laser Energy. Lasers in surgery and medicine · 2021 · PMID 33508141

Abstract summary (English) BACKGROUND AND OBJECTIVES: The 1064 nm wavelength is optimized for dark skin, but within the range of available fluences for commercially available 1064 nm devices, may not provide effective treatment for lighter hair. The 755 nm alexandrite wavelength can treat a full range of hair colors but is not ideal for darker skin. The hypothesis is that a new laser system capable of emitting 755/1064 nm wavelengths...

Journal Article, Randomized Controlled Trial

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tier1 Split-face comparison of grid fractional radiofrequency vs 1064-nm Nd-YAG laser treatment of periorbital rhytides among Filipino patients. Dermatologic therapy · 2020 · PMID 32683735

Abstract summary (English) Despite multiple individual studies proving efficacy of grid fractional monopolar radiofrequency (Grid RF) and near-infrared irradiation 1064-nm long-pulsed neodymium:YAG laser (Laser Genesis), there is a lack of controlled comparative trials between these devices. This study aims to compare the efficacy and safety of Grid RF versus Laser Genesis in the treatment of periorbital rhytides. This is a randomized,...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier1 Safety and efficacy of single pass vs multipass emission with 755 alexandrite laser for all-skin-type hair removal: A pilot study. Dermatologic therapy · 2020 · PMID 32654400

Abstract summary (English) Lasers are considered the most efficient methods for hair reduction. The goal of these devices is to provide long-term effects without adverse reactions. This is a randomized split-body controlled study on body hair removal and pseudofolliculitis (PFC) treatment, comparing the standard single pass (SP) emission with the multipass emission (Moveo handpiece) with 755 alexandrite laser.

Journal Article, Randomized Controlled Trial

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tier1 Lasers for reduction of unwanted hair in skin of colour: a systematic review and meta-analysis. Journal of the European Academy of Dermatology and Venereology : JEADV · 2019 · PMID 31587390

Abstract summary (English) Light-based therapies are one of the most effective and widely used strategies for removal of undesired hair, with a broadly favourable safety profile. However, subjects with pigmented skin are found to be more prone to laser-related adverse events. While prolonged pulse-width and longer treatment duration were proposed to minimize adverse events, the optimal treatment option among available phototherapy modalities...

Journal Article, Meta-Analysis, Systematic Review

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tier1 Randomized, side-by-side comparison of a topical photo-enhancer gel for hair removal: an efficacy and safety study. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2018 · PMID 30300021

Abstract summary (English) Background: Novel protocols are evolving to enhance hair follicle damage while preserving safety and improving efficacy. Objectives: The safety and tolerability of a 755-nm diode laser was compared to a combined laser with topical photo-enhancer gel ("combined") versus laser alone ("solo"). Methods: Twenty women (age 23-33 years old), Fitzpatrick skin type I-V, were randomized to side-by-side...

Journal Article, Randomized Controlled Trial

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tier1 Are lasers superior to lights in the photoepilation of Fitzpatrick V and VI skin types? - A comparison between Nd:YAG laser and intense pulsed light. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2017 · PMID 27911117

Abstract summary (English) BACKGROUND AND OBJECTIVES: There are no large volume comparative studies available to compare the efficacy of lasers over lights for hair removal in Fitzpatrick V and VI skin types. This study is designed to compare the efficacy of Nd:YAG laser versus IPL in the darker skin types. STUDY DESIGN/MATERIALS AND METHODS: Thirty-nine patients included in Group-1 were treated with Nd:YAG and 31 in Group-2 with IPL.

Comparative Study, Journal Article, Randomized Controlled Trial

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Strong evidence base

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