GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Vascular · Leg reticular / spider veins

Vascular pigment laser 532 1064 evidence for Leg reticular / spider veins

B 50.2 / 100 Supported 4 RCT/meta · 5 clinical/observational · 1 case · 20 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2005 Last 5 years 10% Positive results 60% Negative results 1 Korea/Asia 1

Known in Korea as

더마V엑셀V엑셀브이더마V레이저엑셀V 제네시스더마V 싱글/듀얼/트리플

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Long-pulsed 1064nm Nd:YAG laser in the treatment of leg veins: Systematic review. Vascular · 2024 · PMID 38413049

Abstract summary (English) OBJECTIVE: Long-pulsed 1064 nm Nd:YAG laser can damage vessels with higher diameters and penetrate to a deeper level than other laser therapies. We aim to analyze outcomes of the treatment of leg veins with long-pulsed 1064 nm Nd:YAG laser regarding intervention protocol, technical success, clinical success, and side effects. METHODS: A research of the published literature was conducted, using PubMed and Embase...

Journal Article, Systematic Review

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tier1 Clinical comparison of potassium-titanyl-phosphate (KTP) versus neodymium:YAG (Nd:YAG) laser treatment for lower extremity telangiectases. The Journal of dermatological treatment · 2010 · PMID 20666669

Abstract summary (English) BACKGROUND: The Nd:YAG laser has been considered the gold standard of treatment for leg veins, but pain and side effects have fueled physicians to use treatment alternatives. OBJECTIVE: To compare the clinical efficacy of the long-pulsed 1064-nm Nd:YAG laser with KTP laser irradiation in the treatment of leg telangiectasia. METHODS: A series of 16 patients with size-matched superficial telangiectases of the lower...

Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 Clinical comparison of sclerotherapy versus long-pulsed Nd:YAG laser treatment for lower extremity telangiectases. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002 · PMID 12174060

Abstract summary (English) BACKGROUND: Sclerotherapy has traditionally been considered the gold standard of treatment for leg veins, but patient fear of multiple needle injections and side effects of treatment have fueled investigation into other treatment alternatives. As a result, vascular-specific laser and light sources have been developed in an effort to treat these vessels with minimal morbidity and improved efficacy. OBJECTIVE: To...

Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 Treatment of spider leg veins with the KTP (532 nm) laser--a prospective study. Lasers in surgery and medicine · 2002 · PMID 12224093

Abstract summary (English) BACKGROUND AND OBJECTIVES: Spider leg veins are telangiectasias located intracutaneously. This condition poses a cosmetic problem. STUDY DESIGN/PATIENTS AND METHODS: The purpose of this study was to determine what influence the KTP (532 nm) laser has on spider leg veins dependent on the vascular diameter and to what extent the skin has been affected.

Clinical Trial, Journal Article, Randomized Controlled Trial

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tier2 Long-pulsed 1064-nm and 755-nm lasers for C1 leg veins on skin type IV patients: a side-by-side comparison. Lasers in medical science · 2020 · PMID 32748167

Abstract summary (English) Long-pulsed 1064-nm (LP1064) and 755-nm (LP755) lasers have been demonstrated as effective treatments for leg veins. However, few studies of these treatments on Asian skin type as well as direct comparison between two methods were reported. The aim of this study was to compare the clinical efficacy and safety of LP1064 with LP755 in the treatment of C1 leg veins on skin type IV patients.

Comparative Study, Journal Article

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tier2 Treatment of leg telangiectases with a 532 nm KTP laser in multipulse mode. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002 · PMID 12135506

Abstract summary (English) BACKGROUND: The multiple mode emission emphasizes the efficacy of the KTP laser. OBJECTIVE: To evaluate the efficacy of a 532 nm KTP laser emitting in multipulse mode for the treatment of superficial 0.5-1 mm leg telangiectases. METHODS: A 532 nm KTP laser was used in a nonuniform pulse sequence or multipulse mode emission (three stacked pulses of 100 msec, 30 msec, 30 msec, and a delay between pulses of 250 msec),...

Evaluation Study, Journal Article

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tier2 Comparison of the 595 nm long-pulse (1.5 msec) and ultralong-pulse (4 msec) lasers in the treatment of leg veins. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 1999 · PMID 10469090

Abstract summary (English) BACKGROUND: Although several lasers and light sources are now available for vascular lesions, treatment of leg veins has not been very satisfactory. Lengthening the pulse width should theoretically result in improved response rates. OBJECTIVE: This study compared the efficacy and safety of 595 nm pulsed lasers at 1.5 msec and 4 msec in treating leg veins.

Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

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tier2 Comparison of the long-pulse dye (590-595 nm) and KTP (532 nm) lasers in the treatment of facial and leg telangiectasias. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 1998 · PMID 9491116

Abstract summary (English) BACKGROUND: Telangiectasias develop on the face secondary to genetic predisposition, chronic actinic damage, collagen vascular disease, topical steroid application, and disorders of vascular regulation including acne rosacea. Linear and "spider" telangiectasias develop on the legs, especially in women beginning in the second to third decade, secondary to multiple factors including genetic predisposition, gravity,...

Comparative Study, Journal Article

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tier2 Leg telangiectasia treatment with a 1.5 ms pulsed dye laser, ice cube cooling of the skin and 595 vs 600 nm: preliminary results. Lasers in surgery and medicine · 1998 · PMID 9738541

Abstract summary (English) BACKGROUND AND OBJECTIVE: Preliminary results indicate that pulsed dye lasers (PDL) with 1.5 ms pulsewidth and 595 nm wavelength are effective in the treatment of leg telangiectasia. The aim of this study was to evaluate if the clinical results could be improved by a) an effective skin cooling with ice cubes and b) the longer wavelength of 600 nm. STUDY DESIGN/MATERIALS AND METHODS: In 87 patients with vessels up to...

Comparative Study, Journal Article

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tier0_review Pulsed dye laser treatment, a review of indications and outcome based on published trials. British journal of plastic surgery · 2005 · PMID 16039628

Abstract summary (English) INTRODUCTION: Pulsed dye laser (PDL) treatment is based on the principle of selective photothermolysis and is widely considered to be the treatment of choice for a variety of cutaneous vascular lesions. OBJECTIVE: To review the indications and outcome of PDL treatment and summarise new developments. METHOD: A literature-based study has been conducted entailing the review of publications over the period January...

Journal Article, Review

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