GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Vascular · Facial telangiectasia

Vascular pigment laser 532 1064 evidence for Facial telangiectasia

B 55.2 / 100 Supported 31 RCT/meta · 32 clinical/observational · 43 case · 203 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2006 Last 5 years 13% Positive results 58% Negative results 14 Korea/Asia 9

Known in Korea as

더마V엑셀V엑셀브이더마V레이저엑셀V 제네시스더마V 싱글/듀얼/트리플

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Treatment of redness in rosacea with potassium-titanyl-phosphate (KTP) 532 nm laser with and without topical 1% ivermectin cream: a randomized split-face trial. The Journal of dermatological treatment · 2026 · PMID 41778357

Abstract summary (English) UNLABELLED: Objective: Facial erythema and telangiectasia in rosacea are commonly treated with vascular lasers. Combination with ivermectin 1% cream, may enhance outcomes when combined with laser therapy. This study assesses whether topical ivermectin improves the efficacy of Potassium Titanyl Phosphate (KTP) 532 nm laser for facial erythema in rosacea.

Journal Article, Randomized Controlled Trial

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tier1 Long-pulsed 1064nm Nd:YAG laser in the treatment of leg veins: Systematic review. Vascular · 2024 · PMID 38413049

Abstract summary (English) OBJECTIVE: Long-pulsed 1064 nm Nd:YAG laser can damage vessels with higher diameters and penetrate to a deeper level than other laser therapies. We aim to analyze outcomes of the treatment of leg veins with long-pulsed 1064 nm Nd:YAG laser regarding intervention protocol, technical success, clinical success, and side effects. METHODS: A research of the published literature was conducted, using PubMed and Embase...

Journal Article, Systematic Review

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tier1 Comparative Treatment of Mucocutaneous Lesions in Hereditary Haemorrhagic Telangiectasia Patients With Dual Sequential Pulsed Dye Laser and Neodymium: Yttrium-Aluminium-Garnet Versus Neodymium: Yttrium-Aluminium-Garnet Laser Alone: A Double-Blind Randomized Controlled Study With Quality-of-Life Evaluation. Actas dermo-sifiliograficas · 2023 · PMID 37913989

Abstract summary (English) BACKGROUND: Hereditary haemorrhagic telangiectasia (HHT) is characterized by the presence of telangiectases and larger arteriovenous malformations in different organs. Mucocutaneous telangiectases can bleed and become an aesthetic concern, impairing quality of life (QoL). However, the best treatment approach has not been defined yet.

Randomized Controlled Trial, Journal Article

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tier1 Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis. Current allergy and asthma reports · 2023 · PMID 37995018

Abstract summary (English) PURPOSE OF REVIEW: To analyze and compare the effects of epistaxis treatments for Hereditary Hemorrhagic Telangiectasia (HHT) patients. RECENT FINDINGS: Of total of 21 randomized controlled trials (RCT), the data from 15 RCTs (697 patients, 7 treatments: timolol, propranolol, bevacizumab, doxycycline, tacrolimus, estriol/estradiol, and tranexamic acid) were pooled for the meta-analyses while the other 6 studies...

Systematic Review, Journal Article, Network Meta-Analysis

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tier1 Interventions For the Treatment of Lower Limb Telangiectasias and Reticular Veins: A Systematic Review and Network Meta-Analysis. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2023 · PMID 37209995

Abstract summary (English) OBJECTIVE: To assess the safety and efficacy of available interventions in the treatment of lower limb reticular veins and telangiectasias. DATA SOURCES: An electronic search was performed on Scopus, Embase, and Google scholar. REVIEW METHODS: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.

Systematic Review, Journal Article, Network Meta-Analysis

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tier1 Efficacy and safety of intense pulsed light for the treatment of facial erythema: a systematic review and meta-analysis. Italian journal of dermatology and venereology · 2023 · PMID 37166752

Abstract summary (English) INTRODUCTION: Facial erythema can be seen in many patients. Despite various clinical trials exploring the effect of intense pulsed light (IPL) in treating facial erythema, comprehensive evidence about the specific outcomes remains lacking. EVIDENCE ACQUISITION: We searched published studies in the Web of Science, PubMed, Embase, and Cochrane Library databases based on established inclusion criteria.

Meta-Analysis, Systematic Review, Journal Article

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tier1 Nd:Yag laser combined with injection sclerotherapy in the treatment of reticular veins and telangiectasias (CLaCS method): A triple-blind randomized clinical trial comparing two sclerosing agents associated with same laser patterns. Phlebology · 2023 · PMID 36657386

Abstract summary (English) BACKGROUND: Cryo-Laser & Cryo-Sclerotherapy (CLaCS) is a technique which combines thermal sclerotherapy and injection sclerotherapy. Telangiectasias and small varicosities are targeted by a transdermal laser and right after receive injection sclerotherapy. A cooling device blows -20°C air onto the skin and needle in a pre-, parallel-, and post-fashion.

Randomized Controlled Trial, Journal Article

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tier1 Laser therapy for treating hypertrophic and keloid scars. The Cochrane database of systematic reviews · 2022 · PMID 36161591

Abstract summary (English) BACKGROUND: Hypertrophic and keloid scars are common skin conditions resulting from abnormal wound healing. They can cause itching, pain and have a negative physical and psychological impact on patients' lives. Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy.

Journal Article, Research Support, Non-U.S. Gov't, Systematic Review

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tier1 Postinflammatory and rebound hyperpigmentation as a complication after treatment efficacy of telangiectatic melasma with 585 nanometers Q-switched Nd: YAG laser and 4% hydroquinone cream in skin phototypes III-V. Journal of cosmetic dermatology · 2020 · PMID 33002283

Abstract summary (English) BACKGROUND: The potential efficacy of vascular component-targeted laser has been evaluated for the treatment of melasma, which commonly found with the co-existence of telangiectasia. AIMS: To evaluate the treatment efficacy and safety of 585-nm QSNYL and 4% HQ cream combination vs 4% HQ cream alone for telangiectatic melasma in the skin phototypes III-V. PATIENTS/METHODS: Twenty-one Thai female patients with...

Journal Article, Randomized Controlled Trial

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tier1 Laser-Assisted Control of Epistaxis in Hereditary Hemorrhagic Telangiectasia: A Systematic Review. Lasers in surgery and medicine · 2019 · PMID 31441079

Abstract summary (English) BACKGROUND AND OBJECTIVES: Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, causes recurrent mucous membrane hemorrhage, especially epistaxis. In this systematic review, we discuss the efficacies of the three most common laser photocoagulation treatments for HHT-related epistaxis. STUDY DESIGN/MATERIALS AND METHODS: A systematic literature search was conducted in PubMed and...

Journal Article, Research Support, N.I.H., Extramural, Systematic Review

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Suggested interpretation

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