GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Vascular · Cherry angioma

Vascular pigment laser 532 1064 evidence for Cherry angioma

C 47.9 / 100 Supported 6 RCT/meta · 9 clinical/observational · 19 case · 104 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2004 Last 5 years 10% Positive results 43% Negative results 8 Korea/Asia 7

Known in Korea as

더마V엑셀V엑셀브이더마V레이저엑셀V 제네시스더마V 싱글/듀얼/트리플

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Comparative evaluation of laser therapy for infantile hemangiomas: A systematic review of clinical outcomes and treatment considerations. Photodiagnosis and photodynamic therapy · 2025 · PMID 40404110

Abstract summary (English) BACKGROUND AND OBJECTIVES: Infantile hemangiomas (IHs) are the most common benign vascular tumors in infancy. While many resolve spontaneously, treatment is often required due to ulceration, functional impairment, or aesthetic concerns. Laser therapy, either alone or in combination with beta-blockers, has become a central therapeutic option.

Comparative Study, Journal Article, Systematic Review

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tier1 The 595-nm Wavelength Pulsed Dye Laser for Pediatric Port-Wine Birthmarks and Infantile Hemangiomas: A Systematic Review. Lasers in surgery and medicine · 2024 · PMID 39682011

Abstract summary (English) INTRODUCTION: The 595-nm wavelength pulsed dye laser (PDL) is well-established in the treatment of vascular lesions. In June 2023, it received FDA clearance for the treatment of port-wine birthmarks (PWB) and infantile hemangiomas (IH) in the pediatric population. OBJECTIVE: Review the evidence regarding the efficacy, safety, and implications of using PDL for management of pediatric PWB and IH.

Journal Article, Systematic Review

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tier1 The Efficacy and Safety of Topical β-Blockers in Treating Infantile Hemangiomas: A Meta-Analysis Including 11 Randomized Controlled Trials. Dermatology (Basel, Switzerland) · 2020 · PMID 33027794

Abstract summary (English) BACKGROUND: To evaluate the efficacy and safety of topical β-blockers in the treatment of superficial infantile hemangiomas (SIH) and mixed infantile hemangiomas (MIH), respectively, and compare the efficacy and safety of topical β-blockers with other interventions. METHODS: The PRISMA guidelines were adhered to. We searched for randomized controlled trials in databases from 2010 to 2018 comparing topical β-blockers...

Journal Article, Meta-Analysis

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tier1 Treatment Modalities for Cherry Angiomas: A Systematic Review. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020 · PMID 33252464

Abstract summary (English) BACKGROUND: Cherry angiomas are benign vascular proliferations of endothelial cells associated with aging. Currently, no mainstay of treatment for these vascular anomalies exists. OBJECTIVE: To review existing evidence-based therapies for the treatment of cherry angiomas.

Journal Article, Systematic Review

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tier1 Observation on the effects of 595- nm pulsed dye laser and 755- nm long-pulsed alexandrite laser on sequential therapy of infantile hemangioma. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2020 · PMID 32588671

Abstract summary (English) BACKGROUND: Infantile hemangioma (IH) can lead to severe complications. The 595-nm pulsed dye laser is poorly effective on thick and deep IH. Long-pulsed alexandrite laser has the proper wavelength of 755 nm and a relatively deep penetration.

Journal Article, Randomized Controlled Trial

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tier1 Superficial hemangioma is better treated by topical 5-aminolevulinic followed by 595-nm pulsed dye laser therapy rather than 595-nm laser therapy alone. Lasers in medical science · 2017 · PMID 28812167

Abstract summary (English) The aim of this study was to compare the efficacy and adverse effects of a 595-nm pulsed dye laser therapy alone (PDL alone) with a 5-aminolevulinic (5-ALA) local application followed by a 595-nm PDL (5-ALA PDL) in the treatment of superficial hemangioma (SH). A prospectively randomized study in 181 patients with SH was carried out over a period of 24 months. One hundred and ninety-three patients were seen.

Journal Article, Randomized Controlled Trial

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tier1 Topical timolol solution versus laser in treatment of infantile hemangioma: a comparative study. Pediatric dermatology · 2015 · PMID 25740672

Abstract summary (English) Lasers, 595-nm pulsed dye and 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG), have been used successfully for the treatment of infantile hemangiomas (IHs). Recently the use of a topical β-blocker, specifically timolol maleate, has been promising in the treatment of IHs. The objective of this study was to compare the effectiveness of topical timolol 5 mg/mL solution with that of combined sequential...

Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 Pulsed dye laser therapy for infantile hemangiomas: a systemic review and meta-analysis. QJM : monthly journal of the Association of Physicians · 2014 · PMID 25376585

Abstract summary (English) BACKGROUND: Infantile hemangiomas (IH) are common pediatric tumors. This meta-analysis was performed to review the therapeutic efficacy and safety of pulsed dye laser (PDL) in the treatment of IH. METHODS: Seven databases were searched, including PubMed, OvidSP, Karger, Elsevier, EMBASE, Web of Science and Wiley Online Library.

Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review

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tier1 Combination therapy of infantile hemangioma with pulsed dye laser with topical propranolol: a randomized clinical trial. Archives of Iranian medicine · 2014 · PMID 25305763

Abstract summary (English) BACKGROUND: The combination of pulsed dye laser (PDL) and topical propranolol are used with variable effectiveness for the treatment of infantile hemangiomas (IH), particularly for superficial lesions. OBJECTIVE(S): The aim of this study was to investigate whether the therapeutic efficacy of prescribing topical propranolol along with PDL was superior to PDL therapy alone in the treatment of IH. METHODS: A total of...

Journal Article, Randomized Controlled Trial

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tier1 Superficial hemangioma: pulsed dye laser versus wait-and-see. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2012 · PMID 23279058

Abstract summary (English) BACKGROUND AND OBJECTIVES: Childhood hemangioma is the most common soft tissue tumor of infancy, occurring in 10% of children younger than 1 year old. Ten percent of these infantile hemangiomas involute yearly without intervention. Treatment with the pulsed dye laser (PDL) is the criterion standard for treating vascular lesions.

Comparative Study, Journal Article, Randomized Controlled Trial

View on PubMed

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