GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Pigment · Periorbital dark circle

Picosecond laser pigment evidence for Periorbital dark circle

C 37.0 / 100 Insufficient 0 RCT/meta · 1 clinical/observational · 0 case · 2 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2025 Last 5 years 50% Positive results 50%

Known in Korea as

피코슈어피코웨이피코토닝피코플러스피코슈어 프로피코 색소레이저

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier2 Prospective studies of the efficacy and safety of the picosecond 755, 1,064, and 532 nm lasers for the treatment of infraorbital dark circles. Lasers in surgery and medicine · 2017 · PMID 29135036

Abstract summary (English) BACKGROUND: Infraorbital dark circles result from a combination of factors. The fractionated picosecond 755 nm alexandrite laser and dual wavelength picosecond Nd:YAG laser have not been examined as a method of addressing infraorbital hyperpigmentation. OBJECTIVE: To determine the efficacy and safety of treatment of infraorbital dark circles using fractionated picosecond 755 nm and dual wavelength picosecond Nd:YAG...

Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

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tier_other Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation. Journal of visualized experiments : JoVE · 2025 · PMID 40489429

Abstract summary (English) Periorbital hyperpigmentation is a complex condition with multiple underlying causes, such as pigmented, vascular, structural, and mixed factors. The multifaceted nature of the disease presents significant challenges and complexities in its treatment, making it a difficult condition to address effectively. These options include topical cosmetics that can improve the appearance of the affected areas and various...

Journal Article, Video-Audio Media

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Suggested interpretation

Limited evidence

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Concerns of interest (select multiple)
Decision stage
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