Photodynamic therapy evidence for Photodamaged skin / texture

Abstract summary (English) OBJECTIVES: Cellular senescence contributes to skin aging. Lasers and energy-based devices (EBDs) are used to treat age-related skin changes. Given the clinical improvement seen with these devices, we sought to systematically review whether current evidence supports an impact on cellular senescence.

Journal Article, Systematic Review

Abstract summary (English) INTRODUCTION & OBJECTIVES: Treatment with daylight photodynamic therapy (dPDT) of actinic keratosis (AK) is associated with local skin reactions (LSR), which may affect patients' quality of life and treatment acceptability. This study explores the potential of a prebiotic and panthenol-containing Dermocosmetic Cream (DC) to enhance tolerance and mitigate post-dPDT induced LSR in the treatment of AKs. MATERIALS &...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Recently, indoor daylight photodynamic therapy (idl-PDT) has been developed; however, its efficacy and tolerability remain to be assessed. OBJECTIVE: This is a not-inferiority study to compare treatment outcomes of cPDT with a red LED lamp and idlPDT with a polychromatic white LED lamp in adult patients affected by symmetrical AKs of face and/or scalp. METHODS: In this comparative, intra-patient,...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND AND OBJECTIVES: Image-guided quantitative and semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM and OCT features in photoaged skin after light and energy-based therapy.

Journal Article, Randomized Controlled Trial

Abstract summary (English) OBJECTIVE: To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF-RhodoLED® light (635 nm; 37 J/cm² ) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photodamaged skin of the décolleté. METHODS: This was a single-site prospective, randomized, intraindividual...

Case Reports, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Journal Article

Abstract summary (English) BACKGROUND: Lidocaine/tetracaine 7%/7% peel cream (L/T-pC) is very effective in reducing pain in several dermatological procedures, such as hair or tattoo laser removal or conventional photodynamic therapy associated pain. Fractional laser resurfacing (FLR) is an effective treatment strategy for facial skin aging. The main drawback of FLR is the procedure-associated pain.

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Daylight photodynamic therapy (DL-PDT) has similar efficacy to conventional photodynamic therapy in treating actinic keratosis (AKs). Good clinical outcomes have been reported when associated with physical methods such as microneedles, but a comparison of different methods and histologic studies is lacking. OBJECTIVES: To evaluate clinical and histologic modifications induced by standard DL-PDT and...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Light-emitting diodes (LEDs) may be used as an activating light source for photosensitizers in photodynamic therapy (PDT), a form of noninvasive phototherapy. Photodynamic therapy for aesthetic dermatologic conditions has demonstrated skin rejuvenating effects. OBJECTIVE: To evaluate the safety and efficacy of PDT using LEDs to treat aesthetic dermatologic conditions including photoaged skin, scarring,...

Journal Article, Systematic Review

Abstract summary (English) This review analyses physical drug delivery enhancement technologies with a focus on improving UV damaged skin, actinic keratoses and non-melanoma skin cancer treatment. In recent years, physical drug delivery enhancement has been shown to enhance cosmeceutical and skin cancer treatment efficacy, but there are pros and cons to each approach which we discuss in detail. Mechanisms of action, clinical efficacy,...

Journal Article, Research Support, Non-U.S. Gov't, Systematic Review

Abstract summary (English) BACKGROUND AND OBJECTIVES: Décolleté photodamage is a common condition typically treated with light and energy-based devices. This study investigated the efficacy and safety of a fractional 1,927 nm thulium laser (TL) alone and combined with photodynamic therapy (PDT). STUDY DESIGN/MATERIALS AND METHODS: In a 12-week follow-up study, participant décolletés were divided into four treatment areas and randomized to...

Journal Article, Randomized Controlled Trial