Photodynamic therapy evidence for Active inflammatory acne

Abstract summary (English) BACKGROUND: 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for moderate-to-severe acne. However, it is associated with adverse effects, such as erythema, and requires multiple sessions. Supramolecular salicylic acid (SSA) is a type of chemical peel with good anti-inflammatory effects and mild adverse effects.

Journal Article, Randomized Controlled Trial

Abstract summary (English) Procedural therapies are increasingly recognized as effective adjunctive treatments for acne vulgaris alongside topical and systemic options. This systematic review aims to provide a comprehensive overview of the efficacy, safety and relapse rate of various procedural therapies in managing acne vulgaris. Data from 160 studies involving 8121 patients were analyzed across four major databases up to 2024.

Journal Article, Systematic Review

Abstract summary (English) Although topical 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) is an effective treatment for facial acne, many patients report significant pain during the irradiation phase, compromising adherence. Two-step PDT, which modifies irradiance in two phases, has been proposed to reduce pain without compromising treatment efficacy. In this single-center, assessor-blinded randomized trial, 26 patients with facial...

Journal Article, Randomized Controlled Trial

Abstract summary (English) Acne vulgaris is a prevalent skin disorder with significant emotional and psychological impacts. Conventional treatments often have limitations, prompting exploration into alternative therapies like vascular lasers and light treatments. This systematic review evaluates the efficacy and safety of vascular lasers (IPL, PDL, Nd:YAG) on inflammatory acne lesions associated with acne vulgaris.

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Acne vulgaris is a pervasive skin disease characterized by inflammation of sebaceous units surrounding hair follicles. It results from the complex interplay between skin physiology and the intricate cutaneous microbiome. Current acne treatments, while effective, have major limitations, prompting a shift towards microbiome-based therapeutic approaches.

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: ALA-PDT has been widely used in mild to moderate acne vulgaris worldwide. However, very few studies used riboflavin-PDT to treat acne vulgaris. OBJECTIVE: To investigate the efficacy and adverse events of riboflavin-PDT to treat mild to moderate facial acne, and compare it with ALA-PDT on a non-inferiority basis.

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) Acne is a multifactorial disorder of the pilosebaceous unit. Photodynamic therapy (PDT) is an energy-based treatment shown to be safe in acne vulgaris, although the mechanism of action of PDT in acne is incompletely understood. This review summarizes the clinical features of and treatment efficacy in acne patients treated with PDT.

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease involving the pilosebaceous unit. OBJECTIVE: To assess the efficacy and safety of a chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) in the treatment of mild to moderate acne patients. METHODS: In this prospective patient single-blind randomized split-face controlled study, patients diagnosed with mild to moderate acne were treated with...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Acne vulgaris (AV) is a widespread inflammatory skin condition associated with increased sebum production, abnormal keratinization, bacterial overgrowth, and inflammation. Overactive sebaceous glands (SGs) produce excess sebum, promote Cutibacterium acnes growth, and affect acne development. Energy-based treatments (EBDs), including light therapy, photodynamic therapy (PDT), lasers, and radiofrequency...

Journal Article, Systematic Review

Abstract summary (English) OBJECTIVE: To evaluate the efficacy of CO2 fractional laser and microneedling pretreatment combined with ALA-PDT for moderate-to-severe acne, aiming to optimize clinical treatment. METHODS: Patients were randomly divided into three groups: Group A (CO2 fractional laser + ALA-PDT), Group B (microneedling + ALA-PDT), and Group C (ALA-PDT). Each group underwent photodynamic therapy once a week for 3 weeks.

Journal Article, Randomized Controlled Trial, Comparative Study