GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Lifting / Laxity · Body skin laxity

Pdo PCL PLLA thread lifting evidence for Body skin laxity

B 54.6 / 100 Supported 2 RCT/meta · 7 clinical/observational · 10 case · 66 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2022 Last 5 years 59% Positive results 47% Negative results 1 Korea/Asia 8

Known in Korea as

돌기실모노실민트실압토스잼버실LSCO아이쓰레드맞춤 실리프팅실루엣 Fit실루엣 소프트

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Update on Absorbable Facial Thread Lifts. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2024 · PMID 39662017

Abstract summary (English) BACKGROUND: Thread lifts are a noninvasive technique for suspending ptotic skin. Previous studies have failed to show long-term efficacy data with absorbable threads. OBJECTIVE: To review the recent literature evaluating mid and lower facial absorbable thread lifts over a four-year period from October 2018 to December 2022.

Journal Article, Systematic Review

View on PubMed
tier1 Combining red photobiomodulation therapy with polydioxanone threads for wrinkle reduction in the glabella region: A randomized, controlled, double-blind clinical trial. Journal of biophotonics · 2024 · PMID 38934100

Abstract summary (English) The combination of polydioxanone (PDO) threads with other technologies has garnered significant interest for rejuvenation purposes. Photobiomodulation (PBM) has the potential to improve patient comfort and recovery after minimally invasive rejuvenation protocols and also contribute to the overall efficacy of these procedures, fostering an integrative approach to cutaneous rejuvenation. The objective os this work was...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

View on PubMed
tier2 Comparative Analysis of Collagen Induction in Sprague Dawley Rat Model Using Absorbable Threads for Facial Lifting and Rejuvenation. Aesthetic plastic surgery · 2025 · PMID 41436887

Abstract summary (English) BACKGROUND: This study aimed to evaluate the efficacy and biocompatibility of various absorbable threads from Hans BioMed for facial lifting in a Sprague Dawley rat model, focusing on collagen production, inflammatory responses, and overall skin remodeling. METHODS: Six types of absorbable threads, PCL, PDO, PDLLA, PLCL, and two P4HB variants (55 and 90% elongation) from Hans BioMed, were analyzed using...

Journal Article, Comparative Study

View on PubMed
tier2 A Pilot One and Two-Year Prospective, Blinded Clinical Evaluation of Efficacy, and Safety of Combined Treatment With Crosslinked Hyaluronic Acid Dermal Filler and Barbed Polydioxanone Suspension Threads for Mid-Face Contour Enhancement. Journal of cosmetic dermatology · 2024 · PMID 39692727

Abstract summary (English) INTRODUCTION: The combination of hyaluronic acid (HA) fillers and polydioxanone (PDO) thread lifting is gaining popularity for mid-face rejuvenation, especially among the Asian population. Despite the common use of these techniques, there is a paucity of long-term studies assessing their combined efficacy and safety. This study aims to evaluate the efficacy and safety of combined HA filler and PDO thread treatment...

Journal Article, Clinical Trial

View on PubMed
tier2 Advanced Facial Rejuvenation: Synergistic Effects of Lower Blepharoplasty and Ultrasound Guided Mid-Face Lift Using Polydioxanone (PDO) Threads. Aesthetic plastic surgery · 2024 · PMID 38519570

Abstract summary (English) BACKGROUND: Traditional facial aging surgeries have risks and extended recovery times, leading to a demand for minimally invasive alternatives. PDO (polydioxanone) threads, which are absorbable sutures that stimulate collagen production and tissue contraction, offer improved aesthetic outcomes. This paper evaluates the combined use of PDO thread mid-cheek lift and lower blepharoplasty for facial rejuvenation.

Journal Article, Comparative Study

View on PubMed
tier2 Nasolabial fold correction through cheek volume loss restoration versus thread lifting: a comparative study. Archives of dermatological research · 2020 · PMID 31898756

Abstract summary (English) Nasolabial folds are caused by loss of deep fat and subsequent loss of muscle contour in the midface, leading to sagging which forms cosmetic issues in some cases when they are otherwise overly pronounced. Various treatment procedures have been developed to reduce their appearance. The objective of this study is to compare the efficacy of hyaluronic acid (HA) cheek fillers injection and thread lifting in improving...

Comparative Study, Journal Article

View on PubMed
tier2 Stimulation of collagenesis by poly-L-lactic acid (PLLA) and -glycolide polymer (PLGA)-containing absorbable suspension suture and parallel sustained clinical benefit. Journal of cosmetic dermatology · 2020 · PMID 32167231

Abstract summary (English) BACKGROUND: Though the collagen-stimulating capacity of poly-L-lactic acid (PLLA) is well established, no data are available on collagen stimulation by the PLLA/PLGA within absorbable suspension sutures used for tissue repositioning. AIMS: To characterize collagen stimulation by absorbable suspension sutures through examination of patient biopsies and assess severity of nasolabial folds (NLF) over time....

Clinical Trial, Journal Article

View on PubMed
tier2 Comparative effects of various absorbable threads in a rat model. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2018 · PMID 29979893

Abstract summary (English) BACKGROUND: Conventional procedures including botulinum toxin and filler injections have their limitations in improving deep wrinkles and decreasing tissue laxity, and possess the propensity for vascular accidents. Absorbable thread is a recently commercialized field, but there is little evidence on comparative superiority. OBJECTIVES: We observed the effects of polydiaxanone (PDO) threads with different number of...

Comparative Study, Journal Article

View on PubMed
tier2 Two years' outcome of thread lifting with absorbable barbed PDO threads: Innovative score for objective and subjective assessment. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2017 · PMID 28863268

Abstract summary (English) BACKGROUND: Thread-lifting rejuvenation procedures have evolved again, with the development of absorbable threads. Although they have gained popularity among plastic surgeons and dermatologists, very few articles have been written in literature about absorbable threads. This study aims to evaluate two years' outcome of thread lifting using absorbable barbed threads for facial rejuvenation.

Comparative Study, Journal Article

View on PubMed
tier0_review Anatomical considerations for thread-based brow lifting and wrinkle treatment. The Journal of dermatological treatment · 2025 · PMID 39884674

Abstract summary (English) This review explores the anatomical considerations and technical aspects of thread lifting for the forehead and eyebrow, focusing on the relationships between vascular structures, muscular anatomy, and age-related changes in the forehead-eyebrow complex. It highlights the critical importance of understanding neurovascular pathways, particularly the supratrochlear and supraorbital vessels, as well as the appropriate...

Journal Article, Review

View on PubMed

Suggested interpretation

Strong evidence base

Personalized evidence report

Tell us more about your concern
and the Glass Lab bot will build a personalized report for you.

Based on the Pdo PCL PLLA thread lifting · Body skin laxity information on this page, we'll email you an evidence summary tailored to your skin condition and treatment stage.

Concerns of interest (select multiple)
Decision stage
← Other indications for the same procedure group  |  Other procedures for the same indication →