GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Lifting / Laxity · Submental / neck laxity

Monopolar RF lifting evidence for Submental / neck laxity

B 54.5 / 100 Supported 12 RCT/meta · 14 clinical/observational · 8 case · 59 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Includes meta-analysis/SR Median year 2016 Last 5 years 25% Positive results 49% Negative results 3 Korea/Asia 1

Known in Korea as

덴서티볼뉴머세르프써마지올리지오올타이트울써마지튠라이너튠페이스올리지오X

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Efficacy and safety of radiofrequency ablation (RFA) for recurrent metastatic thyroid carcinoma to the lateral neck: a systematic review. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025 · PMID 40652135

Abstract summary (English) AIM: To evaluate the efficacy and safety of radiofrequency ablation (RFA) for lateral cervical recurrence of metastatic thyroid carcinoma compared to revision surgery (after a primary thyroidectomy and selective neck dissection) and RFA in the central compartment or thyroid bed. This review focuses on studies that differentiate between lateral and central neck RFA, as lesion location might influence outcomes and...

Journal Article, Systematic Review, Review

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tier1 Ultrasound‑guided Percutaneous Radiofrequency and Microwave Ablation for Cervical Lymph Node Metastasis from Papillary Thyroid Carcinoma: A Systematic Review and Meta‑analysis of Clinical Efficacy and Safety. Academic radiology · 2025 · PMID 39800601

Abstract summary (English) AIM: To evaluate the efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) for treating cervical lymph node metastasis (CLNM) from papillary thyroid carcinoma (PTC). METHODS: Medline, EMBASE, Web of Science, and Cochrane Library were searched for studies on the efficacy and safety of thermal ablations for treating CLNM from PTC until July 2024. Among 544 papers, 11 articles were reviewed...

Journal Article, Systematic Review, Meta-Analysis

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tier1 Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment. Journal of cosmetic dermatology · 2024 · PMID 39503284

Abstract summary (English) BACKGROUND: Neck wrinkles are a prominent characteristic of skin aging, with recent studies indicating that interventions such as platelet-rich plasma (PRP), microneedling (MN), and radiofrequency (RF) can effectively rejuvenate aging skin. AIMS: This study aims to assess and compare the efficacy of three treatment modalities in addressing neck wrinkles. METHODS: Fifteen female participants with a neck Lemperle...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 A Randomized, Single-Center, Double-Blind, Controlled Case Study Evaluating Procedure Pairing of a Neurocosmetic Postprocedure Cream With Radiofrequency Microneedling for Facial Rejuvenation. Journal of cosmetic dermatology · 2024 · PMID 39385645

Abstract summary (English) BACKGROUND: Radiofrequency (RF) microneedling produces patient discomfort which deters patients from completing the recommended treatment series. OBJECTIVE: The primary objective was to determine the tolerability, safety, and efficacy of a neurocosmetic postprocedure cream post-RF microneedling in reducing patient discomfort and enhancing recovery across the length of the study and, secondarily, to evaluate against...

Journal Article, Randomized Controlled Trial

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tier1 Comparison of the efficacy of Fractional Radiofrequency Microneedling alone and in combination with platelet-rich plasma in neck rejuvenation: a clinical and optical coherence tomography study. Journal of cosmetic dermatology · 2021 · PMID 34214220

Abstract summary (English) BACKGROUND: Esthetic improvement of the neck and cervicomental angle remains one of the most challenging aspects of rejuvenation. Fractional radiofrequency microneedling demonstrated significant skin tightening and lifting of lower third of the face. AIM OF WORK: To evaluate and compare fractional radiofrequency microneedling alone and in combination with autologous platelet-rich plasma (PRP) in neck rejuvenation.

Journal Article, Randomized Controlled Trial

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tier1 A Randomized, Split-Face, Evaluator-Blind Clinical Trial Comparing Monopolar Radiofrequency Versus Microfocused Ultrasound With Visualization for Lifting and Tightening of the Face and Upper Neck. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2019 · PMID 30531187

Abstract summary (English) BACKGROUND: Over the past decade, 2 major modalities for noninvasive skin tightening have emerged: monopolar capacitive-coupled radiofrequency (MRF) and microfocused ultrasound with visualization (MFU-V). Up to date, no comparative clinical trials have been performed. OBJECTIVE: To compare the efficacy and safety of MRF versus MFU-V for the lifting and tightening of the face and neck.

Journal Article, Randomized Controlled Trial

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tier1 A Randomized Evaluator-Blinded Trial Comparing Subsurface Monopolar Radiofrequency With Microfocused Ultrasound for Lifting and Tightening of the Neck. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2017 · PMID 28902019

Abstract summary (English) BACKGROUND: Both subsurface monopolar radiofrequency (SMRF) and microfocused ultrasound with visualization (MFU-V) have demonstrated the ability to lift and tighten the neck. No head-to-head comparison study exists of these 2 technologies. OBJECTIVE: To compare the efficacy and safety of SMRF and MFU-V for the lifting and tightening of neck.

Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 Randomized, blinded, 3-arm clinical trial assessing optimal temperature and duration for treatment with minimally invasive fractional radiofrequency. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2015 · PMID 25915628

Abstract summary (English) BACKGROUND: A previous multicenter clinical trial of a needle-based fractional radiofrequency (FRF) treatment for facial and neck rhytides and laxity counterintuitively demonstrated a mean target temperature and treatment duration of 69.5 °C and 4.9 seconds for subjects with lesser improvement and 67 °C and 4.2 seconds for greater improvement. OBJECTIVE: To determine optimal temperature and duration settings for...

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier1 Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome. The Cochrane database of systematic reviews · 2013 · PMID 23999944

Abstract summary (English) BACKGROUND: This review is an update of a review first published in Issue 2, 2003, which was substantially updated in Issue 7, 2010. The concept that many neuropathic pain syndromes (traditionally this definition would include complex regional pain syndromes (CRPS)) are "sympathetically maintained pains" has historically led to treatments that interrupt the sympathetic nervous system. Chemical sympathectomies use...

Journal Article, Systematic Review

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tier1 Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome. The Cochrane database of systematic reviews · 2010 · PMID 20614432

Abstract summary (English) BACKGROUND: This review is an update on 'Sympathectomy for neuropathic pain' originally published in Issue 2, 2003. The concept that many neuropathic pain syndromes (traditionally this definition would include complex regional pain syndromes (CRPS)) are "sympathetically maintained pains" has historically led to treatments that interrupt the sympathetic nervous system. Chemical sympathectomies use alcohol or phenol...

Journal Article, Systematic Review

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Suggested interpretation

Strong evidence base

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