GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Pigment · Hori macules

Laser toning qswitched or picosecond evidence for Hori macules

C 48.0 / 100 Supported 5 RCT/meta · 2 clinical/observational · 2 case · 16 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2013 Last 5 years 31% Positive results 62% Negative results 1 Korea/Asia 7

Known in Korea as

토닝밀크토닝수소토닝스펙트라레이저 토닝바디착색토닝레블라이트 SI셀룰라이트 토닝지우개 멀티토닝헬리오스 785

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Effectiveness of an epidermal growth factor-containing cream on postinflammatory hyperpigmentation after 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser treatment of acquired bilateral nevus of Ota-like macules (Hori's nevus) in Asians: A split-face, double-blinded, randomized controlled study. Journal of cosmetic dermatology · 2022 · PMID 35066982

Abstract summary (English) BACKGROUND: Epidermal growth factor (EGF) may promote wound healing and decrease laser-induced postinflammatory hyperpigmentation (PIH). OBJECTIVES: To evaluate the effectiveness of an EGF-containing cream on PIH, post-laser erythema, and transepidermal water loss (TEWL) after 1,064-nm Q-Switched Nd: YAG laser treatment of Hori's nevus. METHODS: This is a split-face, double-blinded, randomized, controlled study...

Journal Article, Randomized Controlled Trial

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tier1 A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020 · PMID 32604235

Abstract summary (English) BACKGROUND: Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated. OBJECTIVE: To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians. METHODS: Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled.

Clinical Trial, Phase IV, Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 A randomized control study of the prevention of hyperpigmentation post Q-switched Nd:YAG laser treatment of Hori nevus using topical fucidic acid plus betamethasone valerate cream versus fucidic acid cream. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2012 · PMID 22471899

Abstract summary (English) BACKGROUND: Post-inflammatory hyperpigmentation (PIH) after laser treatment of Hori nevus remains problematic. Prevention and treatment of PIH have limited success. OBJECTIVE: To study the effects on hyperpigmentation using topical antibiotic alone versus combined antibiotic and betamethasone/valerate after 1064 nm Q-switched Nd:YAG laser treatment of Hori nevus.

Journal Article, Randomized Controlled Trial

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tier1 Effect of spot size and fluence on Q-switched alexandrite laser treatment for pigmentation in Asians: a randomized, double-blinded, split-face comparative trial. The Journal of dermatological treatment · 2011 · PMID 21756151

Abstract summary (English) BACKGROUND: Q-switched laser treatment for pigment disorders commonly leads to postinflammatory hyperpigmentation (PIH) in Asians. OBJECTIVES: To evaluate the effect of spot size and fluence on Q-switched alexandrite laser (QSAL) treatment for pigmentation in Asians. METHODS: Ten patients with freckles, 18 with lentigines, and 8 with acquired bilateral nevus of Ota-like macules (ABNOM) received 1 session of QSAL...

Comparative Study, Journal Article, Randomized Controlled Trial

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tier1 Effect of cold air cooling on the incidence of postinflammatory hyperpigmentation after Q-switched Nd:YAG laser treatment of acquired bilateral nevus of Ota like macules. Archives of dermatology · 2007 · PMID 17875874

Abstract summary (English) OBJECTIVE: To investigate the effect of cold air cooling on the incidence of postinflammatory hyperpigmentation (PIH) after laser treatment in Asian patients. DESIGN: Randomized, controlled, split-face study. SETTING: Skin laser center of a university hospital.

Journal Article, Randomized Controlled Trial

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tier2 Association Between Acquired Bilateral Nevus of Ota-Like Macules Patients' Clinical Characteristics and Melasma Induction/Exacerbation After Q-Switched Laser: A Decadal Comparative Study of 2675 Chinese Women in Two Different Periods. Lasers in surgery and medicine · 2025 · PMID 40405427

Abstract summary (English) BACKGROUND: Post-laser melasma induction/exacerbation remains a critical challenge in treating acquired bilateral nevus of Ota-like macules (ABNOMs). While laser parameters are well-studied, patient-specific risk factors across evolving therapeutic eras require elucidation. METHODS: This retrospective cohort analyzed 2675 ABNOMs patients treated with Q-switched lasers in two eras: C1 (2010-2013; 1064 nm-only, n =...

Journal Article, Comparative Study

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tier2 Treatment of acquired bilateral nevus of ota-like macules (Hori's nevus) with a combination of the 532 nm Q-Switched Nd:YAG laser followed by the 1,064 nm Q-switched Nd:YAG is more effective: prospective study. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2006 · PMID 16393596

Abstract summary (English) BACKGROUND: Acquired bilateral nevus of Ota-like macules (Hori's nevus) is a common dyschromatosis among Asian women. Q-switched lasers have been used successfully as a treatment modality. OBJECTIVE: The purpose of this study was to compare the efficacy of using the Q-switched 532 nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser followed by the 1,064 nm laser versus the Q-switched 1,064 nm Nd:YAG laser alone in...

Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

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tier3 Acquired Bilateral Nevus of Ota-Like Macules: A Case Report. Cureus · 2024 · PMID 39184811

Abstract summary (English) Facial melanoses (FM) present complex diagnostic and therapeutic challenges, particularly in the setting of dermal melanocytoses (DM). We present a case that illustrates these challenges as it does not fit within existing classification frameworks. Initially considered as Ota nevus, characterized by blue or dark pigmentation and scleral involvement, histopathological findings suggested acquired bilateral nevus of...

Case Reports, Journal Article

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tier3 Formation of new melasma lesions in the periorbital area following high-fluence, 1064-nm, Q-switched Nd/YAG laser. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2013 · PMID 23656545

Abstract summary (English) Although ultraviolet (UV) light or exogenous hormones have been associated with the development or exacerbation of melasma, the use of laser as a treatment modality has not been cited as a factor linked to the development of melasma lesions. It is unclear whether epidermal trauma caused by laser or other treatment can lead to the formation of a new melasma lesion. We report on the formation of new melasma lesions in...

Case Reports, Journal Article

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tier_other High-fluence 1064nm Q-switched Nd:YAG laser treatment for ectopic Mongolian spot. The Journal of dermatological treatment · 2023 · PMID 37781886

Abstract summary (English) Q-switched neodymium-yttrium aluminum-garnet (Q-switched Nd:YAG) laser has been reported as an effective treatment for nevus of Ota and acquired bilateral nevus of Ota-like macules (ABNOM). Data on ectopic Mongolian spots have rarely been reported.The present study was performed to investigate the treatment efficacy of a high-fluence 1064 nm Q-switched Nd:YAG laser without tissue whitening in ectopic Mongolian...

Journal Article

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