Ionzyme iontophoresis sonophoresis evidence for Photodamaged skin / texture

Abstract summary (English) This review analyses physical drug delivery enhancement technologies with a focus on improving UV damaged skin, actinic keratoses and non-melanoma skin cancer treatment. In recent years, physical drug delivery enhancement has been shown to enhance cosmeceutical and skin cancer treatment efficacy, but there are pros and cons to each approach which we discuss in detail. Mechanisms of action, clinical efficacy,...

Journal Article, Research Support, Non-U.S. Gov't, Systematic Review

Abstract summary (English) BACKGROUND: The stratum corneum of the epidermis is the principal barrier in topical drug delivery. Currently, iontophoresis is incorporated in dermatology management to increase transdermal drug delivery. OBJECTIVE: To evaluate the efficacy and safety of handheld iontophoresis device in enhancing transdermal vitamin C delivery.

Clinical Trial, Journal Article

Abstract summary (English) BACKGROUND: L-ascorbic acid has been widely used to treat photo-aged skin. However, its aqueous formula is prone to oxidation. Therefore, a new formula that contains 23.8% L-ascorbic acid and a chemical penetration enhancer was developed.

Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: Mechanical exfoliation using microdermabrasion has been used as a minimally invasive treatment of photodamage, as well as to improve absorption of topical agents. Phonophoresis, a method of electrically assisted percutaneous delivery of macromolecules, relies on ultrasonic waves producing alterations within the stratum corneum that result in increased absorption. OBJECTIVE: To determine the effects on...

Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) Ionic liquid (ILs) self-assembled micelles (ILs-SAMs) are promising and effective drug delivery systems, which combine the merits of ILs and micelles. Herein, the properties, assembly, functions, and treatments of ILs-SAMs in transdermal drug delivery are summarized. This paper first reviews the fundamental concepts, classifications, assembly mechanisms, characterization techniques, and functional roles of ILs-SAMs.

Journal Article, Review

Abstract summary (English) Skin photoaging, resulting from prolonged exposure to ultraviolet (UV) radiation, is characterized by intricate biological changes involving oxidative damage and structural alterations. Despite an increasing demand for effective interventions, the current therapeutic options for treating skin photoaging are limited. We discovered through literature data search on PubMed that recent research has shifted its focus to...

Journal Article, Review

Abstract summary (English) UV exposure often triggers photoaging of the skin. Pharmacological treatment suffers from severe side effects as well as poor efficacy because of insufficient skin penetration. Dissolved oxygen has been previously shown to reverse photoaged skin; however, the treatment is often limited by the availability of equipment (e.g., high-pressure oxygen).

Journal Article, Review, Research Support, Non-U.S. Gov't

Abstract summary (English) Skin barrier dysfunction and oxidative stress caused by aging and UV exposure often result in pigmentation and photoaging, necessitating safe and effective topical delivery systems. However, co-delivering hydrophilic and lipophilic bioactives remains challenging due to their divergent solubility and stability profiles. To address this, we developed a W/O/W multiple emulsion stabilized by biopolymer-based...

Journal Article

Abstract summary (English) Hydrophilic macromolecules with versatile bioactivities have potential in regenerative medicine and cosmetics but are limited by their inferior transdermal capacity. Here, inspired by the transdermal capacity of silk nanofibers (SNF), recombinant collagen XVII (RCL), a model of hydrophilic macromolecules, was assembled with SNFs to form nanocomplexes. The nanostructures and sizes of the complexes could be controlled...

Journal Article

Abstract summary (English) This study developed a thermostable, high-loading dissolving microneedle (DMN) system for the transdermal delivery of anti-aging ingredients, 3-O-ethyl ascorbic acid (EAC) and acetyl hexapeptide-8 (AH-8). By using a composite matrix of hyaluronic acid (HA) and polyvinyl alcohol (PVA) in a 3:2 ratio and optimizing a two-step vacuum-assisted micromolding process, we successfully addressed key fabrication challenges,...

Journal Article