Injectable lipolysis deoxycholate or mesotherapy evidence for Thigh fat

Abstract summary (English) Although probiotics have been shown to enhance physical endurance, the underlying mechanisms remain unclear. This study investigates the effects of Limosilactobacillus reuteri Culture Collection of Food Microorganisms (CCFM)1388 on exercise endurance and its regulatory role in gut microbiota and host metabolism. A treadmill fatigue model in mice demonstrated that CCFM1388 significantly improved exercise endurance by...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Cellulite is an irregular alteration of the skin surface giving it cottage cheese appearance. Carboxytherapy is transcutaneous infusion of carbon dioxide into the affected site. Mesolipolysis aims to remove cellulite and improve skin texture.

Comparative Study, Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Cellulite of the upper lateral and posterior thighs and lower buttocks represents a common, physiological and unwanted condition whose etiologies and effective management are subjects of continued debate. OBJECTIVE: The purpose of this controlled, double-blinded study is to evaluate the efficacy and safety of a novel phosphatidylcholine-based, cosmeceutical anti-cellulite gel combined with a...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: The role of ATX-101 in submental fat reduction has been well documented; however, its applicability across multiple anatomic areas is to be explored. OBJECTIVES: The authors sought to describe the experience with ATX-101 subcutaneous injections for body and jawline contouring and evaluate its safety. METHODS: This single-arm, single-center observational study included 201 patients who underwent injection...

Observational Study, Journal Article

Abstract summary (English) BACKGROUND: Deoxycholic acid is an FDA-approved injectable for treatment of excess submental fat. OBJECTIVE: Study purpose was to evaluate the safety and efficacy of deoxycholic acid for reduction of upper inner thigh fat. METHODS AND MATERIALS: Fifteen subjects received 2–4 treatment sessions of deoxycholic acid 10 mg/mL injected into upper inner thigh fat.

Clinical Trial, Phase I, Journal Article

Abstract summary (English) BACKGROUND: Phosphatidylcholine, a lecithin extracted from soybeans can reduce serum cholesterol to some extent. Intravenous use may prevent fat embolism in polytrauma patients. When injected intralesionally in a formulation containing also deoxycholate and ethanol it is supposed to act as "fat burner" to reduce undesired fat deposits; there is little evidence-based scientific support for this indication.

Controlled Clinical Trial, Journal Article

Abstract summary (English) The pharmacokinetics of Zn phthalocyanine (ZnPc) encapsulated in dipalmitoyl-phosphatidylcholine (DPPC) liposomes, injected intravenously in Skh:HR-1 nude mice, was monitored by two in vitro techniques and one in vivo technique, all based on fluorescence spectroscopy. The in vitro methods involve either fluorescence measurements on thin tissue sections or on extracts from these tissues. The in vivo method involves...

Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) Proteolytic processing of precursor proteins liberates bioactive fragments, yet the systematic discovery of such peptides remains challenging. Here, we establish a fragment-mining strategy that combines in silico prediction with chemical tailoring to generate self-assembling antimicrobial peptides directly from protein sequences, including previously unannotated proteins. Self-assembly proved integral to activity:...

Journal Article

Abstract summary (English) Targeting delivery to the infection site and good affinity of vehicle to the bacterial are two main concerns in therapy of bacterial infection, and on-demand release of drug is another important issue. In this work, a liposome drug delivery system (HA/P/BAI-lip) incorporated with baicalein and modified by PHMG and HA was prepared. Several characterizations were conducted to examine the physical properties of...

Journal Article

Abstract summary (English) A new reversible complex between troxerutin and phosphatidylcholine (85-90mg/kg per day), in the form of a liposome-like water microdispersion, was topically applied to the rat thigh in an experimental counterpart of acute lymphedema. After four days there was 75% less hindlimb edema (mean decrease 40% of normal compared to control 10% of normal) in the treated compared with the untreated rats. These findings...

Journal Article