Injectable lipolysis deoxycholate or mesotherapy evidence for Flank / love handle

Abstract summary (English) BACKGROUND: Cryolipolysis combined with shockwave therapy has been previously shown to have synergistic effects in body contouring results. OBJECTIVE: This open-label, prospective, multicenter, comparative study investigated the safety and efficacy of combined cryolipolysis, shockwave therapy with cryolipolysis, shockwave therapy, and injection polyenylphosphatidylcholine-based lipolysis. METHODS: Enrolled patients...

Clinical Trial, Comparative Study, Journal Article, Multicenter Study

Abstract summary (English) A 39-year-old woman presented with a 14.0cm by 10.0cm lipoma on the left posterior-lateral flank. Conventional treatment for lipomas includes excision, but this poses a risk of extensive scarring in patients with large lipomas. Deoxycholic acid (DCA) injections are a viable non-surgical alternative to reduce the size of lipomas.

Case Reports, Journal Article

Abstract summary (English) Biological membranes are characterized by a heterogeneous composition, which is not only manifested in the wide variety of their components, but also in aspects like the lateral organization, topology, and conformation of proteins and lipids. In bringing about the correct membrane structure, protein-lipid interactions can be expected to play a prominent role. The extent of hydrophobic matching between transmembrane...

Journal Article, Research Support, Non-U.S. Gov't, Review

Abstract summary (English) Purpose To characterize lipidomic profiles in the VX2 rabbit tumor model and assess potential lipid plasticity across tumor microenvironments in the liver and flank. Materials and Methods VX2 tumors were implanted into the liver in four rabbits and both flanks in two rabbits. After 10-14 days, tumor-containing tissues were harvested, snap frozen, sectioned, and analyzed using matrix-assisted laser desorption...

Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Abstract summary (English) BACKGROUND: Deoxycholic acid (DCA) injection is a noninvasive method for localized fat reduction, offering lower risks compared to invasive techniques. This study evaluates the safety and efficacy of DCA injections for reducing flank fat. AIMS: We assessed the efficacy and safety of DCA injections for flank fat reduction over a 12-week period using imaging, anthropometric data, Global Aesthetic Improvement Scale...

Journal Article

Abstract summary (English) AIM: To evaluate the efficacy of ursodeoxycholic acid (UDCA) as a chemotherapeutic agent for the treatment of hepatocellular carcinoma (HCC). METHODS: BALB/c nude mice were randomized into four groups 24 h before subcutaneous injection of hepatocarcinoma BEL7402 cells suspended in phosphate buffered saline (PBS) into the right flank. The control group (n = 10) was fed a standard diet while treatment groups (n = 10...

Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) CTP:phosphocholine cytidylyltransferase (CCT), the regulatory enzyme in the synthesis of phosphatidylcholine, is activated by binding membranes using a lipid-induced amphipathic helix (domain M). Domain M functions to silence catalysis when CCT is not membrane engaged. The silencing mechanism is unknown.

Journal Article, Research Support, Non-U.S. Gov't

Abstract summary (English) The membrane-spanning segments of integral membrane proteins often are flanked by aromatic or charged amino acid residues, which may "anchor" the transmembrane orientation. Single spanning transmembrane peptides such as those of the WALP family, acetyl-GWW(LA)(n)LWWA-amide, furthermore adopt a moderate average tilt within lipid bilayer membranes. To understand the anchor residue dependence of the tilt, we introduce...

Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Abstract summary (English) Finasteride is indicated orally in the treatment of androgenetic alopecia and some other pilosebaceous unit (PSU) disorders. We wished to investigate whether topical application of finasteride-containing vesicles (liposomes and niosomes) could enhance drug concentration at the PSU, as compared to finasteride hydroalcoholic solution (HA). Liposomes consisted of phospholipid (dimyristoyl phosphatidylcholine (DMPC) or...

Journal Article

Abstract summary (English) Alopecia areata (AA) is a chronic cutaneous disease with a suspected autoimmune origin. We evaluated the efficacy of 0.5% Cyclosporin A (CyA) in a topically applied liposomal formulation as a potential treatment for AA using the Dundee Experimental Bald Rat (DEBR) model. The vehicle consisted of liposomes (75% phosphatidylcholine, 5% lysophosphatidylcholine, 5% sterol, natural oils) of 10% wt.

Journal Article