Lifting / Laxity · Lower face / jowls
HIFU lifting evidence for Lower face / jowls
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2021 Last 5 years 50% Positive results 70% Korea/Asia 5
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 A Systematic Review of High-Intensity Focused Ultrasound in Skin Tightening and Body Contouring.
Abstract summary (English) High-intensity focused ultrasound (HIFU) has emerged as a noninvasive technology for aesthetic applications, offering skin tightening, facial rejuvenation, and body contouring. This systematic review assesses its clinical efficacy, safety profile, patient satisfaction, and future advancements. A comprehensive search of studies published between January 2010 and October 2024 identified 45 clinical trials and cohort...
Journal Article, Systematic Review
View on PubMedtier1 Prospective, Single-arm, Split-face Pain Management Evaluation of Nitrous Oxide System During Micro-Focused Ultrasound With Visualization.
Abstract summary (English) BACKGROUND: Although micro-focused ultrasound with visualization (MFU-V) has great cosmetic results, patients can be hesitant or decline the treatment due to the pain experienced during the treatment. The primary objective is to assess the efficacy of pain management of the nitrous oxide system during MFU-V treatment. The secondary objectives include patient satisfaction and efficacy on reducing facial laxity and...
Journal Article, Randomized Controlled Trial
View on PubMedtier1 Combination of Calcium Hydroxylapatite Diluted With Normal Saline and Microfocused Ultrasound With Visualization for Skin Tightening.
Abstract summary (English) Background/Objectives: Treatment options for the correction of age-related changes in skin include the use of energy-based devices and dermal fillers. In this study, we evaluate the clinical efficacy and tolerability of microfocused ultrasound with visualization (MFU-V) and injectable calcium hydroxylapatite (CaHA) filler diluted with normal saline, for the correction of age-related changes and to assess patients'...
Journal Article, Randomized Controlled Trial
View on PubMedtier2 Efficacy and Safety of Microwave Energy-Based Device for Facial Rejuvenation: A Retrospective Comparative Study With High-Intensity Focused Ultrasound.
Abstract summary (English) BACKGROUND: Facial aging is characterized by soft tissue atrophy, subcutaneous fat redistribution, and dermal laxity, most pronounced in the lower face and submental region. High-intensity focused ultrasound (HIFU) is the benchmark noninvasive lifting modality, whereas microwave energy-based devices (MEBDs) have recently emerged, targeting adipose tissue and dermis. Although MEBD has been validated in body...
Journal Article, Comparative Study
View on PubMedtier2 Intense focused ultrasound for neck and lower face skin tightening a prospective study.
Abstract summary (English) BACKGROUND: Intense focused ultrasound (IFUS) is a Nonablative skin tightening technology with good safety profile, but limited efficacy. Most clinical studies have been performed to evaluate the efficacy of the Ulthera IFUS (Ulthera, Mesa, AZ) in treating redundant skin. OBJECTIVE: To report our experience with Doublo IFUS (Doublo™, HIRONIC Co.) for treating neck and lower face laxity.
Journal Article, Observational Study
View on PubMedtier2 Evaluation of Micro-Focused Ultrasound for Lifting and Tightening Neck Laxity.
Abstract summary (English) BACKGROUND: A novel device using micro-focused ultrasound with high-resolution ultrasound visualization (MFU-V) produces non-invasive lifting and tightening of lax skin on the face and neck when treatment is delivered at a single focal depth (Ulthera® System; Ulthera, Inc., Mesa, AZ).
OBJECTIVE: The following study was performed to test the hypothesis that customized application of MFU-V at two focal depths...
Evaluation Study, Journal Article
View on PubMedtier2 Evaluation of a microfocused ultrasound system for improving skin laxity and tightening in the lower face.
Abstract summary (English) BACKGROUND: The Ulthera System (Ulthera, Inc, Mesa, Arizona) employs microfocused ultrasound to cause discrete focal heating of the dermis and stimulate neocollagenesis and elastin remodeling. OBJECTIVES: The authors investigated tightening and lifting of cheek tissue, improvement in jawline definition, and reduction in submental skin laxity in patients treated with the Ulthera System. METHODS: A total of 103 adults...
Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
View on PubMedtier0_review A Systematic Review of the Clinical Efficacy of Micro-Focused Ultrasound Treatment for Skin Rejuvenation and Tightening.
Abstract summary (English) The demand for non-invasive skin-tightening techniques is continuously on the rise, as now numerous patients seek safe and effective alternative body, neck, and facial aesthetic surgical procedures. Micro-focused ultrasound (MFU) has been recently introduced as a novel energy modality for skin rejuvenation to produce a more significant wound healing response at various levels, including strong collagen remodeling...
Journal Article, Review
View on PubMedtier_other Thermal Accumulation and Collagen Remodeling in Porcine Models: Parameter-Dependent Efficacy of Micro-Focused Ultrasound for Human Facial Skin Tightening.
Abstract summary (English) BACKGROUND: Skin laxity, driven by collagen/elastin degradation and aging, is targeted by micro-focused ultrasound (MFU) through depth-specific thermal coagulation to induce collagen remodeling, yet parameter-dependent thermal kinetics and safety thresholds remain underexplored, limiting protocol optimization. AIMS: To validate the dose-effect relationship of MFU using in vitro porcine skin tissues and evaluate its...
Journal Article
View on PubMedtier_other Early Experience With Ultherapy Prime in Asia Pacific: A Pilot Case Series.
Abstract summary (English) BACKGROUND: Microfocused ultrasound with real-time visualization is well established as a safe and effective treatment for noninvasive skin lifting. Ultherapy Prime is an updated treatment with an advanced processor and improved imaging capabilities that uses microfocused ultrasound with real-time visualization technology to stimulate tissue remodeling and tightening to improve skin laxity. As published data on...
Journal Article
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