GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Acne / Scar / Texture · Atrophic acne scar - rolling

Fractional laser resurfacing evidence for Atrophic acne scar - rolling

B 54.2 / 100 Supported 8 RCT/meta · 1 clinical/observational · 0 case · 15 total
Good evidence · positive conclusion

There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2022 Last 5 years 67% Positive results 73% Negative results 1 Korea/Asia 1

Known in Korea as

프락셀프락셀/피코프락셀

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Comparison of multiple 1565 nm fractional Er: glass laser and single fractional CO2 laser in the treatment of atrophic acne scars: a prospective, randomized split-face study. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2025 · PMID 39930716

Abstract summary (English) Both ablative fractional laser (AFL) and non-ablative fractional laser (NAFL) are gaining popularity in the treatment of atrophic acne scars. However, single NAFL may not be as effective as single AFL in clinical practice. This split-face and evaluator-blind study compared the efficacy and safety of multiple consecutive NAFL (1565 nm Er: glass laser) and a single AFL (10600 nm CO2 laser) in the treatment...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 PDO screw threads versus fractional CO2 laser, after subcision, for atrophic acne scar remodelling: a randomized group-based comparative study. Archives of dermatological research · 2025 · PMID 39804529

Abstract summary (English) Atrophic acne scars present a significant therapeutic challenge. While subcision with various adjunctive treatments, including fractional CO₂ lasers and polydioxanone (PDO) threads, has been employed for scar remodeling, comparative evidence on their efficacy remains limited. This study aims to compare the clinical efficacy and patient satisfaction between subcision with fractional CO₂ laser and subcision with PDO...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 Comparison of the fractionated Nd: YAG 1064-nm picosecond laser with holographic optics and the fractional CO2 laser in atrophic acne scar treatment: a prospective, randomized, split-face study. International journal of dermatology · 2024 · PMID 38924534

Abstract summary (English) KEY POINT: The 1064-nm picosecond laser with holographic optics demonstrated significant efficacy in treating atrophic acne scars. BACKGROUND: Picosecond lasers with fractionated optics have enabled the development of a breakthrough skin rejuvenation method. The authors compared the fractionated, non-ablative neodymium-doped yttrium aluminum garnet 1064-nm picosecond laser with holographic optics and the fractional...

Journal Article, Randomized Controlled Trial, Comparative Study

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tier1 [Prospective randomized controlled trial on 2 940 nm fractional erbium laser combined with fractional micro-plasma radiofrequency in the treatment of facial atrophic acne scars]. Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023 · PMID 37805765

Abstract summary (English) Objective: To compare the efficacy and safety of 2 940 nm fractional erbium laser combined with fractional micro-plasma radiofrequency (FMR) therapy and 2 940 nm fractional erbium laser in the treatment of atrophic acne scars. Methods: A prospective randomized controlled research was conducted. A total of 100 atrophic acne scar patients (38 males and 62 females, aged 18-37 years) who were treated in...

Randomized Controlled Trial, English Abstract, Journal Article

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tier1 Split-face comparative study of fractional Er:YAG laser versus microneedling radiofrequency in treatment of atrophic acne scars, using optical coherence tomography for assessment. Journal of cosmetic dermatology · 2021 · PMID 33721385

Abstract summary (English) BACKGROUND: Efficacy and safety of ablative fractional laser used for treatment of acne scars have been described in several studies. Recently, microneedling radiofrequency treatment has been showing promising results with low risk of side effects and rapid healing time. OBJECTIVE: To study efficacy and safety of ablative fractional Er:YAG laser 2940 nm and microneedling radiofrequency for facial atrophic acne scar.

Journal Article, Randomized Controlled Trial

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tier1 Split-face clinical comparative study of fractional Er:YAG (2940nm) laser versus long pulsed Nd:YAG (1064nm) laser in treatment of atrophic acne scar. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2021 · PMID 34409915

Abstract summary (English) Despite various modalities used for treating acne scars, no single treatment modality was significantly satisfactory. We compare the efficacies of fractional Erbium: yttrium aluminum garnet (Er:YAG), 2940 nm, laser versus long-pulsed Neodymium: yttrium-aluminum-garnet (Nd:YAG), 1064 nm, laser for the treatment of acne scars. Twenty patients were treated in a randomized split-face manner.

Journal Article, Randomized Controlled Trial

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tier1 Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study. Acta dermato-venereologica · 2020 · PMID 33073298

Abstract summary (English) A variety of applications of human adipose tissue stem cell-derived exosomes have been suggested as novel cell-free therapeutic strategies in the regenerative and aesthetic medical fields. This study evaluated the clinical efficacy and safety of adipose tissue stem cell-derived exosomes as an adjuvant therapy after application of fractional CO2 laser for acne scars. A 12-week prospective, double-blind, randomized,...

Journal Article, Randomized Controlled Trial

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tier1 Fractional CO2 laser versus combined platelet-rich plasma and fractional CO2 laser in treatment of acne scars: Image analysis system evaluation. Journal of cosmetic dermatology · 2019 · PMID 30964227

Abstract summary (English) BACKGROUND: Fractional CO2 laser and platelet-rich plasma (PRP) treatments have been used in the treatment of acne scars. However, an objective method of assessment has been lacking. OBJECTIVE: To evaluate the efficacy of CO2 laser versus the combination of PRP and fractional CO2 laser in treatment of acne scar.

Comparative Study, Journal Article, Randomized Controlled Trial

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tier2 Efficacy and safety of 1550-nm fractional laser in the treatment of acne scars in Chinese patients: A split-face comparative study. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology · 2016 · PMID 27183153

Abstract summary (English) OBJECTIVE: To evaluate the efficacy and side effects of 1550-nm fractional Er:Glass laser in treating atrophic acne scar. MATERIALS AND METHODS: Thirty Chinese patients aged 18-65 with atrophic acne scars on both cheeks received a split-face treatment, one side with four sessions of treatment with fractional 1550-nm Er:Glass laser at 20-day interval and the other with topical asiaticoside cream application three...

Comparative Study, Journal Article

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tier_other Fractional Erbium YAG Laser Resurfacing Versus 20% Trichloroacetic Acid Chemical Peeling in the Treatment of Acne Scars: A Comparative Study. Journal of cutaneous and aesthetic surgery · 2023 · PMID 38314354

Abstract summary (English) BACKGROUND: Acne scarring not only affects the aesthetic appearance of an individual but also has a detrimental effect on mental health and social life. Various treatment modalities are available for acne scars. AIM: In this study, fractional erbium-doped yttrium-aluminum-garnet (Er:YAG) laser resurfacing was compared with 20% trichloroacetic acid (TCA) peeling in terms of efficacy and safety.

Journal Article

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Suggested interpretation

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