Exosome topical or injection evidence for Atopic dermatitis

Abstract summary (English) Adipose-derived mesenchymal stem cells (ADMSCs) offer a multifaceted approach to treating immune-mediated skin diseases by modulating the immune system and promoting tissue regeneration. Specifically, their ability to differentiate into multiple cell types such as keratinocytes and fibroblasts, modulate immune responses, and release growth factors and cytokines underscores their potential in treating a wide range of...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Exosomes, an emerging treatment of interest to aesthetic dermatology, have therapeutic applications in skin rejuvenation, alopecia, atopic dermatitis, acne scarring, and wound healing. Platelet-rich plasma has been widely utilized for the same indications, among others. Currently, there are no trials comparing the two regenerative modalities in aesthetic dermatology.

Comparative Study, Controlled Clinical Trial, Equivalence Trial, Journal Article

Abstract summary (English) Extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strategy for skin barrier repair due to their ability to mediate intercellular communication through the delivery of bioactive cargo including proteins, lipids, and nucleic acids. This review synthesises current evidence on the role of EVs in restoring skin barrier integrity, with a particular focus on atopic dermatitis (AD) and chronic...

Journal Article, Review

Abstract summary (English) Extracellular vesicles (EVs) are lipid bilayer-enclosed particles released by both eukaryotic and prokaryotic cells and represent an evolutionarily conserved system of intercellular communication. By transporting bioactive cargo, including proteins, lipids, microRNAs, EVs enable the transfer of molecular signals between cells, thereby regulating immune homeostasis and inflammatory responses. In allergic diseases,...

Journal Article, Review

Abstract summary (English) Exosomes are pivotal biological entities implicated in both pathogenesis and treatment of various dermal disorders. Their unique structure comprising intracellular proteins, growth factors, and diverse nucleic acids such as mRNA and siRNA enables them to act as key regulators of intercellular communication. Therefore, exosomes can be considered as a double-edged weapon in dermal health, contributing to both disease...

Journal Article, Review

Abstract summary (English) Human breast milk is a dynamic biological fluid enriched with bioactive components, including extracellular vesicle-derived microRNAs (miRNAs), which have emerged as potential mediators of early immune programming. Growing evidence suggests that maternal atopic status can alter the breast milk miRNA profile, potentially shaping the infant's susceptibility to atopic disorders, such as atopic dermatitis, asthma, and...

Journal Article, Review

Abstract summary (English) Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell-based therapies. This study aims to review the composition, mechanisms of action, and dermatologic applications of...

Journal Article, Review

Abstract summary (English) Cell-mediated drug delivery systems represent a promising frontier in dermatologic therapy by offering enhanced targeting precision, prolonged drug release, and reduced systemic toxicity. These systems leverage the intrinsic properties of immune cells, stem cells, and skin-resident cells to migrate toward inflamed or diseased skin and deliver therapeutic agents in a controlled and biocompatible manner. This review...

Journal Article, Review

Abstract summary (English) Recent advances have highlighted exosomes as promising therapeutic, prognostic, and diagnostic agents in dermatology and aesthetic medicine, suggesting their expanding role in various skin conditions. This comprehensive review examines the current applications and future directions of exosomes in dermatological practice. The analysis of available literature reveals a growing market of exosome-based products...

Journal Article, Review

Abstract summary (English) Inflammatory skin diseases such as psoriasis, atopic dermatitis, vitiligo, and lupus erythematosus present persistent therapeutic challenges due to their chronic nature, immune dysregulation, and suboptimal treatment outcomes. Stem cell-derived exosomes have emerged as a promising cell-free therapeutic approach, capable of modulating immune responses, promoting tissue regeneration, and restoring skin homeostasis....

Journal Article, Review