Exosome topical or injection evidence for Androgenetic alopecia - male

Abstract summary (English) BACKGROUND: Microneedling combined with exosome therapy has growing clinical relevance in dermatology. This systematic review will critically evaluate current evidence on the combined use of microneedling and exosomes in a number of dermatological diseases. METHOD: A systematic literature search was conducted using terms related to exosomes and microneedling using 3 databases in accordance with the Preferred...

Systematic Review, Journal Article

Abstract summary (English) Alopecia areata (AA) is an autoimmune-mediated nonscarring alopecia with limited therapeutic options and frequent relapses. Exosomes, nanosized extracellular vesicles secreted by various cell types, have recently emerged as potential regenerative and immunomodulatory therapies. The aim of the study is to review the clinical and preclinical evidence regarding the efficacy and safety of EV-based therapies for alopecia...

Journal Article, Systematic Review

Abstract summary (English) Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and discoid lupus erythematosus (DLE) are lymphocytic cicatricial alopecias causing irreversible follicular loss. Procedural therapies have been proposed to control inflammation, remodel scarred tissue, and, occasionally, promote hair regrowth. We performed a PRISMA-guided systematic review of PubMed/Medline, Ovid Embase, and Scopus through July 28, 2025,...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Exosomes are small extracellular vesicles with potential roles in modulating the hair growth cycle and are an emerging therapy for patients with alopecia. In recent years, researchers have made significant progress in deciphering the network of cellular interactions and signaling pathways mediated by the transfer of exosomes. This has opened the door to a wide range of potential therapeutic applications...

Systematic Review, Journal Article

Abstract summary (English) BACKGROUND: Hair graying is an age-associated condition primarily caused by the depletion and dysfunction of melanocyte stem cells within hair follicles. Emerging regenerative strategies, including exosome-based therapies, offer the potential to restore pigmentation by targeting underlying cellular mechanisms. OBJECTIVE: To investigate the clinical outcomes and correlates of hair repigmentation following...

Journal Article, Observational Study

Abstract summary (English) Thinning hair affects the quality of life of affected men and women but has limited treatment options. A novel technology refines exosomes from stem cells to create a concentrated complex that is quickly absorbed into the scalp to deliver growth factors, peptides, coenzymes, minerals, amino acids, and vitamins (Exosome Regenerative Complex+®. BENEV, Inc.; Mission Viejo, CA).

Clinical Trial, Journal Article

Abstract summary (English) BACKGROUND: The use of micrografts (MCGs) containing human follicle mesenchymal stem cells (HF-MSCs) is a hair loss (HL) treatment that needs to be standardized as seems to have promising effects on hair regrowth (HR-G) also thanks to the presence of extracellular vesicles (EVs). OBJECTIVES: The study aims to report both the in vivo results, obtained in patients affected by androgenic alopecia (AGA) treated using...

Journal Article, Multicenter Study, Observational Study

Abstract summary (English) BACKGROUND: Non-scarring alopecias, including androgenetic alopecia and alopecia areata, are common hair loss disorders with significant psychosocial impact. Conventional treatments such as minoxidil, finasteride, corticosteroids, and platelet-rich plasma (PRP) often demonstrate variable efficacy, relapse rates, or adverse effects. Emerging interest in regenerative dermatology has positioned exosome-based therapy as...

Journal Article, Review

Abstract summary (English) BACKGROUND: Exosomes, nano-sized extracellular vesicles derived from various cell types, have emerged as a promising therapeutic modality in trichology. These vesicles deliver bioactive molecules, such as growth factors, cytokines, and microRNAs, that regulate key cellular processes, including proliferation, differentiation, and signaling, which are critical for hair follicle regeneration. AIM: This review...

Journal Article, Review

Abstract summary (English) BACKGROUND AND PURPOSE: Non-scarring alopecia, principally androgenetic alopecia and alopecia areata is highly prevalent and psychologically burdensome; androgenetic alopecia is androgen-driven, whereas alopecia areata is autoimmune. This review synthesizes genetic architecture and pathway biology to outline a precision framework for targeted interventions. EXPERIMENTAL APPROACH: We reviewed full-text studies from...

Journal Article, Review