Cryolipolysis body contouring evidence for Submental fat
There is a relatively good level of clinical evidence, and a majority of papers support its effectiveness.
Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.
Includes meta-analysis/SR Median year 2018 Last 5 years 35% Positive results 82%
Known in Korea as
Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.
Key papers
tier1 Cryolipolysis for Submental Fat Reduction: A Systematic Review and Meta-Analysis.
Abstract summary (English) Submental fat can be addressed using both surgical and nonsurgical techniques. Cryolipolysis is a noninvasive treatment that uses cold temperatures to trigger apoptosis in adipose tissue.This study aims to evaluate the efficacy and safety of cryolipolysis for submental fat reduction, specifically analyzing changes in submental fat thickness and volume. It is hypothesized that cryolipolysis leads to measurable...
Journal Article, Systematic Review, Meta-Analysis
View on PubMedtier2 Cryolipolysis for local fat reduction in adults from Brazil: A single-arm intervention study.
Abstract summary (English) BACKGROUND: Localized fat is a matter of great concern among individuals from today's society. Cryolipolysis is a noninvasive technique that have shown great results in reducing localized fat. AIMS: To analyze the efficacy of cryoplipolysis on visible local fat reduction in submental region, arms, or male breast (pseudogynecomastia) in Brazilian subjects, and to assess possible factors associated with treatment...
Clinical Trial, Journal Article
View on PubMedtier2 Safety and Efficacy of Bilateral Submental Cryolipolysis With Quantified 3-Dimensional Imaging of Fat Reduction and Skin Tightening.
Abstract summary (English) IMPORTANCE: Cryolipolysis is a popular, well-tolerated nonsurgical procedure that uses controlled cooling to selectively destroy fat cells. Central submental cryolipolysis has been reported to be safe and effective, but many patients would benefit from extending this treatment over the entire submental region. OBJECTIVE: To investigate the safety and efficacy of cryolipolysis for reduction of lateral and central...
Clinical Trial, Journal Article
View on PubMedtier2 Safety and efficacy of cryolipolysis for non-invasive reduction of submental fat.
Abstract summary (English) BACKGROUND AND OBJECTIVES: Cryolipolysis has previously received FDA clearance for fat reduction in the abdomen, flanks, and thighs. There is also interest in small volume fat reduction for areas such as the chin, knees, and axilla. This article reports the results of a cryolipolysis pivotal IDE study for reduction of submental fullness.
Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
View on PubMedtier0_review Cryolipolysis for the treatment of submental fat: Review of the literature.
Abstract summary (English) BACKGROUND: Submental fat accumulation is a common cosmetic concern. Cryolipolysis utilizes noninvasive cooling to lyse adipocytes. A cryolipolysis device was recently approved for treatment of submental fat.
Journal Article, Review
View on PubMedtier0_review Noninvasive approach to treatment of submental fullness.
Abstract summary (English) A recent survey done by the American Society for Dermatologic Surgery indicated that 67% of respondents were bothered by "excess fat under the chin/neck." Accumulation of fat in the preplatysmal compartment of the neck is a common cause for fullness in the submental area. In the past, surgical liposuction was the only option to remove fat in the submental area. Although effective, liposuction does have risks and...
Journal Article, Review
View on PubMedtier0_review Neck Contouring and Treatment of Submental Adiposity.
Abstract summary (English) There have been many recent and significant innovations to the cosmetic physician's repertoire for addressing excess submental fat and improving patients' neck contour. These new techniques include submental cryolipolysis, injectable chemical lipolysis, percutaneous radiofrequency, laser techniques, and liposuction with or without laser or power assistance. These modalities range from completely non-invasive to...
Journal Article, Review
View on PubMedtier0_review ATX-101 (deoxycholic acid injection) for reduction of submental fat.
Abstract summary (English) INTRODUCTION: The shape and contour of the chin and neck play an important role in facial esthetics. As such, excess fat within the submental area (double chin) can negatively affect facial esthetics and body image. Common treatments for submental contouring include invasive procedures such as surgical rejuvenation and targeted liposuction.
Journal Article, Review
View on PubMedtier0_review Neck Rejuvenation Using a Combination Approach: Our Experience and a Review of the Literature.
Abstract summary (English) BACKGROUND: Aging of the neck is characterized by changes that include skin dyspigmentation, laxity, rhytides, loss of the mandibular contour, widening of the cervicomental angle, accumulation of submental fat, volume loss and prominence of the platysmal bands. Many cosmetic options exist to address these changes individually, but little literature exists about the safety and efficacy of combining such procedures...
Journal Article, Review
View on PubMedtier_other "A Systematic Review of Injectable Lipolytic agents for Non-Submental Fat Reduction".
Abstract summary (English) INTRODUCTION: Injectable lipolytic agents have gained popularity as a non-invasive approach to localized fat reduction. While deoxycholic acid (DCA) remains the only FDA-approved agent for submental fat reduction, its application for non-submental regions is an emerging area of interest. This systematic review evaluates existing literature on injectable lipolytic agents beyond the submental region.
Journal Article
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