GLASS LAB · Medical Aesthetics Evidence Index 303 cells · 19,226 papers · 5,969 top-tier evidence

Body / Fat · Flank / love handle

Cryolipolysis body contouring evidence for Flank / love handle

C 40.6 / 100 Supported 1 RCT/meta · 8 clinical/observational · 3 case · 25 total
Early-stage evidence

This is an early evidence stage based mainly on observational studies and case reports. Use it as supplementary reference, and follow your doctor's judgment for treatment decisions.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2016 Last 5 years 4% Positive results 48% Negative results 2 Korea/Asia 3

Known in Korea as

쿨스컬프팅젤틱 쿨슬리밍

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier1 Three-dimensional volumetric quantification of fat loss following cryolipolysis. Lasers in surgery and medicine · 2013 · PMID 24535759

Abstract summary (English) BACKGROUND AND OBJECTIVES: Cryolipolysis is a noninvasive and well-tolerated treatment for reduction of localized subcutaneous fat. Although several studies demonstrate the safety and efficacy of this procedure, volumetric fat reduction from this treatment has not been quantified. This prospective study investigated the change in volume of fat after cryolipolysis treatment using three-dimensional (3D) photography.

Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

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tier2 Adverse Events Associated with Cryolipolysis Treatment for Body Contouring: A Prospective Observational Study with 3-Month Follow-Up. Plastic and reconstructive surgery · 2025 · PMID 40875252

Abstract summary (English) BACKGROUND: Many clinical studies have recently assessed the efficacy and safety of cryolipolysis, a nonsurgical procedure for body contouring. This study aimed to analyze the incidence and duration of transient adverse events (AEs) after cryolipolysis treatment. METHODS: This was a prospective observational study of outpatients in aesthetic medical group clinics.

Journal Article, Observational Study

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tier2 Effective noninvasive body contouring by using a combination of cryolipolysis, injection lipolysis, and shock waves. Journal of cosmetic dermatology · 2019 · PMID 30980602

Abstract summary (English) BACKGROUND: Cryolipolysis combined with shockwave therapy has been previously shown to have synergistic effects in body contouring results. OBJECTIVE: This open-label, prospective, multicenter, comparative study investigated the safety and efficacy of combined cryolipolysis, shockwave therapy with cryolipolysis, shockwave therapy, and injection polyenylphosphatidylcholine-based lipolysis. METHODS: Enrolled patients...

Clinical Trial, Comparative Study, Journal Article, Multicenter Study

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tier2 Effects of contrast cryolipolysis on flank region adiposity: Case study. Journal of cosmetic dermatology · 2018 · PMID 30246297

Abstract summary (English) BACKGROUND: The Contrast Cryolipolysis is a non-invasive technique that aims to reduce localized adiposity with its heating-cooling-heating method, resulting in a 45% fat loss in the treated area, with no damage to the skin. OBJECTIVE: To investigate the effects of contrast cryolipolysis compared to conventional cryolipolysis on localized adiposity. MATERIALS AND METHODS: This is a case study was carried out with...

Comparative Study, Journal Article

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tier2 The use of bovine serum albumin-glutaraldehyde tissue adhesive (BioGlue®) for tumor bed closure following open partial nephrectomy. Actas urologicas espanolas · 2017 · PMID 28283215

Abstract summary (English) OBJECTIVES: To report the results of the use of Bovine Serum Albumin-Glutaraldehyde tissue adhesive (BioGlue®) for tumor bed closure in open nephron-sparing surgery (NSS). MATERIALS AND METHODS: The cohort included 255 patients with enhancing renal mass who underwent open NSS. We used open flank approach, with in-situ hypothermia and enucleation of the tumor.

Evaluation Study, Journal Article

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tier2 Robot-assisted partial nephrectomy with intracorporeal renal hypothermia using ice slush: step-by-step technique and matched comparison with warm ischaemia. BJU international · 2015 · PMID 26435486

Abstract summary (English) OBJECTIVES: To outline our step-by-step technique for intracorporeal renal cooling during robot-assisted partial nephrectomy (RAPN). PATIENTS AND METHODS: Patient selection was performed during a preoperative clinic visit. Cases where we estimated during preoperative assessment that warm ischaemia time would be >30 min, as determined by whether the patient had a complex renal mass, were selected.

Comparative Study, Journal Article

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tier2 Non-invasive fat reduction of the flanks using a new cryolipolysis applicator and overlapping, two-cycle treatments. Lasers in surgery and medicine · 2014 · PMID 25395266

Abstract summary (English) BACKGROUND AND OBJECTIVES: A sharply contoured cryolipolysis vacuum applicator was developed to improve fit and tissue draw in the abdomen and flanks to better accommodate a range of body types and a variety of treatment sites. This study was carried out to evaluate the safety and efficacy of the new applicator for treatment of flank fat ("love handles"). STUDY DESIGN/MATERIALS AND METHODS: A cryolipolysis vacuum...

Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

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tier2 Longitudinal evaluation of cryolipolysis efficacy: two case studies. Journal of cosmetic dermatology · 2013 · PMID 23725309

Abstract summary (English) Cryolipolysis treatment, or cold-induced destruction of adipocytes, provides a noninvasive option for localized subcutaneous fat reduction without damaging the overlying skin or adjacent structures. This case study examines the long-term visibility of fat layer reduction subsequent to cryolipolysis treatment, through longitudinal evaluation. Two male subjects were unilaterally treated on one flank.

Case Reports, Controlled Clinical Trial, Journal Article

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tier2 Tissue precooling for thermochemical damage reduction during laser surgery. Lasers in surgery and medicine · 1987 · PMID 3613807

Abstract summary (English) This report describes a preliminary investigation of the possibility of reducing the thermal damage induced by lasers in the course of laser surgery. Skin incisions made by CO2 laser beams--with and without precooling--were evaluated and compared with scalpel cuts. Full thickness cuts were carried out on the flank of adult cats.

Comparative Study, Journal Article

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tier0_review Anatrophic nephrolithotomy. Urology · 2001 · PMID 11164167

Abstract summary (English) INTRODUCTION: Anatrophic nephrolithotomy is a procedure in which a parenchymal incision is made in an intersegmental plane, allowing removal of large renal calculi. TECHNICAL CONSIDERATIONS: A flank incision is made and the kidney carefully mobilized. The main renal artery is isolated and the posterior segmental artery identified.

Journal Article, Review

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