CaHA filler evidence for Photodamaged skin / texture

Abstract summary (English) BACKGROUND: Nasolabial folds (NLFs), the pronounced furrows extending from the base of the nose to the corners of the mouth, tend to deepen and lengthen as a natural consequence of aging. Currently, one of the most prevalent treatments for NLFs involves injectable tissue fillers. Although various types of fillers have been utilized in clinical settings, there exists a paucity of research dedicated to evaluating...

Journal Article, Comparative Study, Meta-Analysis

Abstract summary (English) BACKGROUND: The diverse ethnic skin phenotypes and socioeconomic landscape of Latin America (LATAM) necessitate tailored approaches to collagen biostimulators, calcium hydroxylapatite (CaHA) and poly-l-lactic acid (PLLA). A region-specific consensus on their optimal use is lacking. OBJECTIVES: To establish expert consensus guidelines on patient selection, techniques, and practical application of CaHA and PLLA for...

Journal Article, Systematic Review, Consensus Statement

Abstract summary (English) BACKGROUND: The use of dermal fillers has become increasingly popular in aesthetic medicine for facial rejuvenation and skin enhancement. Hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) are particularly well-known for their unique benefits. This systematic review evaluates the combinations (e.g., using two separate treatments together) and hybrid treatments of HA and CaHA (e.g., direct syringe-to-syringe...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Facial aging leads to cosmetically unappealing volume loss in the temples. We systematically reviewed the available literature regarding nonsurgical temporal volumization with injectable fillers. METHODS: On Sept 16, 2024, Medline, Scopus, Embase, and Cochrane databases were queried with relevant terms for all articles describing temporal volumization with injectable fillers, including those with...

Journal Article, Systematic Review

Abstract summary (English) Although microfocused ultrasound with visualization (MFU-V) and calcium hydroxylapatite- carboxymethylcellulose (CaHA-CMC) have their individual strengths and have demonstrated effectiveness in aesthetic improvement and improving skin laxity, a combined treatment may sometimes be required to achieve comprehensive aesthetic enhancements that meet patients' needs and preferences. This review systematically summarizes...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: The selection of dermal fillers in aesthetic medicine often relies on factors such as cost, immediate outcomes, and practitioner experience. However, incorporating knowledge of fillers' rheological properties, such as viscoelasticity and cohesiveness, allows for more precise product selection tailored to patient needs and treatment goals while reducing the risk of complications. AIMS: This review aims to...

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Microfocused ultrasound with visualization (MFU-V) and hyperdilute calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) dermal injections are effective for improving skin laxity in the lower face and submentum by stimulating neocollagenesis and neoelastogenesis. OBJECTIVES: Combining these treatments in an optimal order may inform best practice in aesthetic dermatology. Despite their frequent...

Journal Article, Randomized Controlled Trial

Abstract summary (English) BACKGROUND: Injectable biostimulator treatments stimulate endogenous collagen in aging skin, but whether they act through similar pathways is unknown. This study evaluates two biostimulatory agents' effects on genes, expressed proteins, and respective pathways as potential aging biomarkers and treatment outcomes. METHODS: This 13-week, randomized, single-center, comparative study compared volume change and gene...

Journal Article, Randomized Controlled Trial, Comparative Study

Abstract summary (English) INTRODUCTION: Aesthetic medicine has evolved towards minimally invasive procedures, with biostimulators like Poly-L-Lactic Acid (PLLA), Calcium Hydroxylapatite (CaHA), and Polycaprolactone (PCL) gaining attention for their role in collagen induction, improving skin texture, elasticity, and volume. Combining these agents with other treatments-such as botulinum toxin, dermal fillers, and energy-based devices (e.g....

Journal Article, Systematic Review

Abstract summary (English) BACKGROUND: Injectable biostimulators are widely used to improve facial aging signs. This study was performed to compare the genetic pathways affected by 2 different injectable biostimulators. METHODS: Randomized 13-week study (n = 21) comparing gene expression after poly l-lactic acid (PLLA-SCA) and calcium hydroxylapatite (CaHA-R) injections (baseline [BL] and Day 28) as treatment of nasolabial fold wrinkles.

Journal Article, Comparative Study, Randomized Controlled Trial