What is the evidence for Adipose matrix (Renuva) treating Body localized volume defect?

Confidence grade F (13 / 100). PubMed has 0 tier-1 papers (RCT, meta-analysis, systematic review), 0 tier-2 (clinical trial, observational), 0 tier-3 (case). Direction: insufficient.

What does the literature conclude about Adipose matrix (Renuva) for Body localized volume defect?

Fewer than 3 papers state a clear outcome direction. Insufficient data to draw a conclusion.

Volume / Contour · Body localized volume defect

Adipose matrix (Renuva) evidence for Body localized volume defect

F 13.2 / 100 Insufficient 0 RCT/meta · 0 clinical/observational · 0 case · 2 total

Insufficient evidence

There is not yet enough PubMed evidence for this combination. The procedure exists, but research on this indication may be scarce.

Grade combines the quantity and quality of the research, while direction is a separate signal showing how the papers assess effectiveness.

Median year 2026 Last 5 years 50% Positive results 50%

Known in Korea as

renuva

Procedure and brand names vary, but the evidence above applies to the same procedure mechanism.

Key papers

tier_other DAT-delivered astaxanthin reprograms adipogenesis through RhoGDI1 dephosphorylation at Ser174 and RhoA/FAK/ERK1/2 cascade suppression. Biomaterials · 2026 · PMID 41506140

Abstract summary (English) Adipose tissue serves as a primary approach for soft tissue defect repair, but clinical regeneration remains limited by inadequate adipogenic capacity. While astaxanthin (AST) can ameliorate adipose dysfunction, the underlying mechanisms governing its pro-adipogenic activity remain elusive. Here, we developed an AST-loaded decellularized adipose tissue (DAT) hydrogel with the aim of boosting adipogenic potential.

Journal Article

View on PubMed

tier_other External Volume Expansion Adjusted Adipose Stem Cell by Shifting the Ratio of Fibronectin to Laminin. Tissue engineering. Part A · 2019 · PMID 31347463

Abstract summary (English) External volume expansion (EVE) is an effective method of adipose tissue regeneration. However, it remains unclear how EVE induces adipose tissue regeneration. In this study, we developed EVE devices to generate expanded prefabricated adipose tissue (EPAT) in rats and investigated cell proliferation, adipogenesis, and the expression of extracellular matrix (ECM) proteins during the 12 weeks suction.

Journal Article, Research Support, Non-U.S. Gov't

View on PubMed

Suggested interpretation

Needs further review

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Adipose matrix (Renuva) evidence for Body localized volume defect

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